Sugi Predict

Sugi Predict / Compounds / SCHEMBL10162147

SCHEMBL10162147

SCHEMBL10162147

CC(=O)c1ccc2c(c1C)CC[C@@H]2NC(=O)c1cc(C(=O)NCc2ccc3c(c2)OC(F)(F)O3)nc2c(F)cnn12

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ADAMTS4 O75173 2/20 0.68
▸ MMP3 P08254 2/20 0.68
▸ MMP13 P45452 2/20 0.68
▸ MMP8 P22894 1/20 0.56
▸ MMP12 P39900 1/20 0.56
▸ KIT P10721 7/20 0.35
▸ BRAF P15056 7/20 0.35
▸ RORC P51449 1/20 0.35
▸ KDM4E B2RXH2 2/20 0.34
▸ ALDH1A1 P00352 2/20 0.34
▸ HPGD P15428 2/20 0.34
▸ KMT2A Q03164 2/20 0.34
▸ NPSR1 Q6W5P4 2/20 0.34
▸ MEN1 O00255 1/20 0.34
▸ PDE2A O00408 2/20 0.34
▸ MAPK1 P28482 1/20 0.34
▸ RPS6KA1 Q15418 1/20 0.34
▸ ROCK2 O75116 1/20 0.33
▸ KCNH2 Q12809 1/20 0.32
▸ DHODH Q02127 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10161561 0.96 MMP13 (0.68) ADAMTS4MMP3MMP13MMP8MMP12
SCHEMBL10167288 0.95 MMP13 (0.76) ADAMTS4MMP3MMP13MMP8MMP12
SCHEMBL10162049 0.95 MMP13 (0.68) ADAMTS4MMP3MMP13MMP8MMP12
SCHEMBL10166482 0.91 ADAMTS4 (0.65) ADAMTS4MMP3MMP13MMP8MMP12
SCHEMBL8252927 0.91 MMP13 (0.76) ADAMTS4MMP3MMP13MMP8MMP12
SCHEMBL10161557 0.91 ADAMTS4 (0.69) ADAMTS4MMP3MMP13MMP8MMP12
SCHEMBL13161144 0.91 ADAMTS4 (0.69) ADAMTS4MMP3MMP13MMP8MMP12
SCHEMBL14446760 0.90 ADAMTS4 (0.57) ADAMTS4MMP3MMP13MMP8MMP12
SCHEMBL10161587 0.90 ADAMTS4 (0.67) ADAMTS4MMP3MMP13MMP8MMP12
SCHEMBL13161152 0.90 ADAMTS4 (0.66) ADAMTS4MMP3MMP13MMP8MMP12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8835441-B2 Heterobicyclic metalloprotease inhibitors AMGEN INC. (US) 2014-09-16 — — US disclosed
US-20120015920-A1 HETEROBICYCLIC METALLOPROTEASE INHIBITORS ALANTOS PHARMACEUTICALS HOLDING, INC. (US) 2012-01-19 — — US disclosed
US-7795245-B2 Heterobicyclic metalloprotease inhibitors Atlantos Pharmaceuticals Holding, Inc. (US) 2010-09-14 — — US disclosed
US-20090312312-A1 Heterobicyclic Metalloprotease Inhibitors ALANTOS PHARMACEUTICALS HOLDING, INC. (US) 2009-12-17 — — US disclosed
US-20090137547-A1 Heterobicyclic metalloprotease inhibitors ALANTOS PHARMACEUTICALS HOLDING, INC. 2009-05-28 — — US disclosed
US-20070155738-A1 Heterobicyclic metalloprotease inhibitors ALANTOS PHARMACEUTICALS, INC. 2007-07-05 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090312312-A1 Heterobicyclic Metalloprotease Inhibitors MMP13, TIMP3, MMP3 ADAMTS4 38/4885MMP3 3/4885MMP13 1/4885
US-20120015920-A1 HETEROBICYCLIC METALLOPROTEASE INHIBITORS MMP13, TIMP3, MMP3 ADAMTS4 38/4885MMP3 3/4885MMP13 1/4885
US-20090137547-A1 Heterobicyclic metalloprotease inhibitors MMP13, TIMP3, MMP3 ADAMTS4 38/4885MMP3 3/4885MMP13 1/4885
US-20070155738-A1 Heterobicyclic metalloprotease inhibitors MMP13, TIMP3, MMP3 ADAMTS4 38/4885MMP3 3/4885MMP13 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.