Known targets — ChEMBL curated mechanism
823298382338688239847Rdl1Rdl2Rdl3
The experimentally established mechanism targets of Lindane. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lindane SCHEMBL4354321 | 0.96 | LMNA (0.36) | LMNACYP3A4GABRA1GABRB1GABRG2 | |
| Lindane SCHEMBL333037 | 0.96 | LMNA (0.36) | LMNACYP3A4GABRA1GABRB1GABRG2 | |
| Lindane SCHEMBL2579810 | 0.96 | LMNA (0.36) | LMNACYP3A4GABRA1GABRB1GABRG2 | |
| Lindane SCHEMBL28684263 | 0.84 | LMNA (0.46) | LMNACYP3A4GABRA1GABRB1GABRG2 | |
| Lindane SCHEMBL555867 | 0.84 | LMNA (0.46) | LMNACYP3A4GABRA1GABRB1GABRG2 | |
| Lindane SCHEMBL28681567 | 0.84 | LMNA (0.46) | LMNACYP3A4GABRA1GABRB1GABRG2 | |
| Lindane SCHEMBL4515334 | 0.83 | — | — | |
| Lindane SCHEMBL15641482 | 0.80 | LMNA (0.42) | LMNACYP3A4GABRA1GABRB1GABRG2 | |
| Lindane SCHEMBL2580519 | 0.80 | LMNA (0.42) | LMNACYP3A4GABRA1GABRB1GABRG2 | |
| SCHEMBL634685 | 0.78 | CA2 (0.46) | LMNACA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2943466-A1 | NOVEL SYNTHESIS INTERMEDIATES FOR OBTAINING DERIVATIVES OF SPHINGOSINES, CERAMIDES AND SPHINGOMYELINS WITH GOOD YIELDS | M2I DEVELOPMENT (FR) | 2015-11-18 | — | — | EP | claimed |
| WO-2014108564-A1 | NOVEL SYNTHESIS INTERMEDIATES FOR OBTAINING DERIVATIVES OF SPHINGOSINES, CERAMIDES AND SPHINGOMYELINS WITH GOOD YIELDS | M2I DEVELOPMENT (FR) | 2014-07-17 | — | — | WO | claimed |
| US-20090107851-A1 | Electrolytic polishing method of substrate | EBARA CORPORATION (JP) | 2009-04-30 | — | — | US | claimed |
| EP-3643694-B1 | METHOD FOR PRODUCING BUTADIENE COMPOUND | DAIKIN IND LTD (JP) | 2023-11-15 | — | — | EP | disclosed |
| WO-2023063301-A1 | METHOD FOR PRODUCING FLUORINATED AROMATIC COMPOUND | ダイキン工業株式会社 | 2023-04-20 | — | — | WO | disclosed |
| WO-2023282261-A1 | LAMINATE, SIGHT LINE TRACKING SYSTEM, AND HEAD-MOUNTED DISPLAY | 富士フイルム株式会社 | 2023-01-12 | — | — | WO | disclosed |
| EP-4090651-A1 | FUNGICIDAL AMIDES | FMC CORPORATION (US) | 2022-11-23 | — | — | EP | disclosed |
| WO-2022210595-A1 | POLYMERIZABLE COMPOSITION, PHOTOCURABLE ADHESIVE AGENT, CURED PRODUCT MANUFACTURING METHOD, AND CURED PRODUCT | 株式会社ADEKA | 2022-10-06 | — | — | WO | disclosed |
| WO-2022152274-A1 | FGFR INHIBITOR COMPOUND AND USE THEREOF | 深圳康溯医药科技有限公司 | 2022-07-21 | — | — | WO | disclosed |
| WO-2021125021-A1 | COMPOSITION, CURED PRODUCT, AND METHOD FOR PRODUCING CURED PRODUCT | 株式会社ADEKA | 2021-06-24 | — | — | WO | disclosed |
| EP-3643694-A1 | METHOD FOR PRODUCING BUTADIENE COMPOUND | Daikin Industries, Ltd. (JP) | 2020-04-29 | — | — | EP | disclosed |
| US-20040077835-A1 | Chemokine receptor modulators, production and use | AMYLIN PHARMACEUTICALS, INC. | 2004-04-22 | — | — | US | disclosed |
| US-6664022-B1 | Forming relief image on substrate by coating with amplified positive resin and iodinium or sulfonium compound comprising naphthyl, thienyl or pentafluorophenyl substituents; exposure to patterned activating radiation; development | SHIPLEY COMPANY, L.L.C. | 2003-12-16 | — | — | US | disclosed |
| EP-0361506-A2 | Crosslinkable composition of fluorine-containing elastomer | DAIKIN INDUSTRIES, LIMITED (JP) | 1990-04-04 | — | — | EP | disclosed |
| EP-0291761-A2 | Terminally unsaturated macromolecular monomers of polylactones and copolymers thereof | THE B.F. GOODRICH COMPANY (US) | 1988-11-23 | — | — | EP | disclosed |
| US-4472494-A | MALEIC ANHYDRIDE-STYRENE COPOLYMER, PHOTORESIST | NAPP SYSTEMS (USA), INC. (US) | 1984-09-18 | — | — | US | disclosed |
| EP-0049577-B1 | ALPHA-CYANOPHENOXYBENZYLAMINE DERIVATIVES, PROCESSES FOR PREPARING THEM, AND THEIR USE AS INTERMEDIATES FOR THE PREPARATION OF PYRETHROID INSECTICIDES | ICI AUSTRALIA LIMITED (AU) | 1984-04-11 | — | — | EP | disclosed |
| US-4420614-A | CHEMICAL INTERMEDIATES, PYRETHROIDS | ICI AUSTRALIA LIMITED (AU) | 1983-12-13 | — | — | US | disclosed |
| EP-0049577-A1 | Alpha-cyanophenoxybenzylamine derivatives, processes for preparing them, and their use as intermediates for the preparation of pyrethroid insecticides | ICI AUSTRALIA LIMITED (AU) | 1982-04-14 | — | — | EP | disclosed |
| WO-1982001085-A1 | BILAYER PHOTOSENSITIVE IMAGING ARTICLE | NAPP SYSTEMS INC (US) | 1982-04-01 | — | — | WO | disclosed |