Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 5/20 | 0.41 |
| ▸ | CACNA1G | O43497 | 4/20 | 0.41 |
| ▸ | CACNA1H | O95180 | 4/20 | 0.41 |
| ▸ | CACNA1I | Q9P0X4 | 4/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 3/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | SCD | O00767 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10162336 | 0.93 | MMP13 (0.49) | PDPK1MAPK1MMP13EPHX2 | |
| SCHEMBL10162345 | 0.92 | MAPK1 (0.43) | MAPK1MMP13 | |
| SCHEMBL10162346 | 0.91 | MMP13 (0.44) | PDPK1MMP13EPHX2 | |
| SCHEMBL10162361 | 0.91 | AKT3 (0.43) | MAPK1 | |
| SCHEMBL10162369 | 0.89 | RIPK1 (0.44) | PDPK1MMP13EPHX2 | |
| SCHEMBL10162358 | 0.89 | EPHX2 (0.36) | PDPK1MAPK1PDGFRAMMP13EPHX2 | |
| SCHEMBL10162500 | 0.88 | MMP13 (0.40) | PDPK1CACNA1GCACNA1HCACNA1IMAPK1 | |
| SCHEMBL10162359 | 0.88 | MMP13 (0.47) | PDPK1CACNA1GCACNA1HCACNA1IMAPK1 | |
| SCHEMBL10165651 | 0.87 | MMP13 (0.46) | CACNA1GCACNA1HCACNA1IMAPK1PDGFRA | |
| SCHEMBL10162460 | 0.86 | MMP13 (0.45) | CACNA1GCACNA1HCACNA1IPDGFRAMMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8835441-B2 | Heterobicyclic metalloprotease inhibitors | AMGEN INC. (US) | 2014-09-16 | — | — | US | disclosed |
| US-20120015920-A1 | HETEROBICYCLIC METALLOPROTEASE INHIBITORS | ALANTOS PHARMACEUTICALS HOLDING, INC. (US) | 2012-01-19 | — | — | US | disclosed |
| US-7795245-B2 | Heterobicyclic metalloprotease inhibitors | Atlantos Pharmaceuticals Holding, Inc. (US) | 2010-09-14 | — | — | US | disclosed |
| US-20090312312-A1 | Heterobicyclic Metalloprotease Inhibitors | ALANTOS PHARMACEUTICALS HOLDING, INC. (US) | 2009-12-17 | — | — | US | disclosed |
| US-20090137547-A1 | Heterobicyclic metalloprotease inhibitors | ALANTOS PHARMACEUTICALS HOLDING, INC. | 2009-05-28 | — | — | US | disclosed |
| US-20070155738-A1 | Heterobicyclic metalloprotease inhibitors | ALANTOS PHARMACEUTICALS, INC. | 2007-07-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090312312-A1 | Heterobicyclic Metalloprotease Inhibitors | MMP13, TIMP3, MMP3 | PDPK1 2525/4885CACNA1G 2170/4885CACNA1H 2465/4885 |
| US-20120015920-A1 | HETEROBICYCLIC METALLOPROTEASE INHIBITORS | MMP13, TIMP3, MMP3 | PDPK1 2525/4885CACNA1G 2170/4885CACNA1H 2465/4885 |
| US-20090137547-A1 | Heterobicyclic metalloprotease inhibitors | MMP13, TIMP3, MMP3 | PDPK1 2525/4885CACNA1G 2170/4885CACNA1H 2465/4885 |
| US-20070155738-A1 | Heterobicyclic metalloprotease inhibitors | MMP13, TIMP3, MMP3 | PDPK1 2525/4885CACNA1G 2170/4885CACNA1H 2465/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.