Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 3/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 10/20 | 0.42 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.41 |
| ▸ | PDE2A | O00408 | 1/20 | 0.40 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.40 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8246459 | 0.94 | MMP13 (0.44) | MMP13HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL10165604 | 0.93 | MMP13 (0.46) | MMP13HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL10162454 | 0.92 | MMP13 (0.42) | MMP13HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL8252305 | 0.91 | MMP13 (0.44) | MMP13HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL10165624 | 0.88 | MMP13 (0.39) | MMP13HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL13185481 | 0.88 | MAPK1 (0.39) | MMP13MAPK1RPS6KA1 | |
| SCHEMBL8256775 | 0.88 | MMP13 (0.39) | MMP13HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL8247779 | 0.88 | MMP13 (0.39) | MMP13HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL10162208 | 0.88 | MMP13 (0.41) | MMP13MAPK1DGAT1PDE2ARPS6KA1 | |
| SCHEMBL10162517 | 0.88 | MAPK1 (0.41) | MMP13MAPK1RPS6KA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120015920-A1 | HETEROBICYCLIC METALLOPROTEASE INHIBITORS | ALANTOS PHARMACEUTICALS HOLDING, INC. (US) | 2012-01-19 | — | — | US | disclosed |
| US-20120015920-A1 | HETEROBICYCLIC METALLOPROTEASE INHIBITORS | ALANTOS PHARMACEUTICALS HOLDING, INC. (US) | 2012-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120015920-A1 | HETEROBICYCLIC METALLOPROTEASE INHIBITORS | MMP13, TIMP3, MMP3 | MMP13 1/4885HDAC3 80/4885HDAC1 104/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.