Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 13/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.65 |
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | MAOB | P27338 | 2/20 | 0.53 |
| ▸ | ACHE | P22303 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1104921 | 0.89 | APP (1.00) | APPCYP1A2NPC1RAB9AMEN1 | |
| SCHEMBL19630613 | 0.87 | APP (0.77) | APPCYP1A2NPC1RAB9AMAOB | |
| SCHEMBL29809000 | 0.87 | APP (0.79) | APPCYP1A2NPC1RAB9AMAOB | |
| SCHEMBL563335 | 0.87 | APP (0.79) | APPCYP1A2NPC1RAB9AMAOB | |
| SCHEMBL563392 | 0.85 | APP (1.00) | APPCYP1A2NPC1RAB9AMAOB | |
| SCHEMBL31115697 | 0.85 | APP (1.00) | APPCYP1A2NPC1RAB9AMAOB | |
| SCHEMBL25735939 | 0.82 | APP (0.79) | APPCYP1A2NPC1RAB9AMEN1 | |
| SCHEMBL10167882 | 0.82 | APP (1.00) | APPCYP1A2NPC1RAB9AACHE | |
| SCHEMBL19627047 | 0.82 | APP (0.70) | APPCYP1A2 | |
| SCHEMBL19627050 | 0.81 | APP (0.78) | APPCYP1A2MAOBACHEMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240024490-A1 | BIFUNCTIONAL MOLECULES FOR SELECTIVE MODIFICATION OF TARGET SUBSTRATES | THE BROAD INSTITUTE, INC. | 2024-01-25 | — | — | US | disclosed |
| US-20240024490-A1 | BIFUNCTIONAL MOLECULES FOR SELECTIVE MODIFICATION OF TARGET SUBSTRATES | THE BROAD INSTITUTE, INC. | 2024-01-25 | — | — | US | disclosed |
| US-20230192904-A1 | BIFUNCTIONAL CHIMERIC MOLECULES FOR LABELING OF KINASES WITH TARGET BINDING MOIETIES AND METHODS OF USE THEREOF | THE BROAD INSTITUTE, INC. | 2023-06-22 | — | — | US | disclosed |
| US-20230192904-A1 | BIFUNCTIONAL CHIMERIC MOLECULES FOR LABELING OF KINASES WITH TARGET BINDING MOIETIES AND METHODS OF USE THEREOF | THE BROAD INSTITUTE, INC. | 2023-06-22 | — | — | US | disclosed |
| US-9216974-B2 | Phenoxazine derivatives and methods of use thereof | WASHINGTON UNIVERSITY (US) | 2015-12-22 | — | — | US | disclosed |
| US-9216974-B2 | Phenoxazine derivatives and methods of use thereof | WASHINGTON UNIVERSITY (US) | 2015-12-22 | — | — | US | disclosed |
| US-9115099-B2 | Phenoxazine derivatives and methods of use thereof | WASHINGTON UNIVERSITY (US) | 2015-08-25 | — | — | US | disclosed |
| US-9115099-B2 | Phenoxazine derivatives and methods of use thereof | WASHINGTON UNIVERSITY (US) | 2015-08-25 | — | — | US | disclosed |
| US-20150175589-A1 | PHENOXAZINE DERIVATIVES AND METHODS OF USE THEREOF | UNIV WASHINGTON (US) | 2015-06-25 | — | — | US | disclosed |
| US-20150175589-A1 | PHENOXAZINE DERIVATIVES AND METHODS OF USE THEREOF | UNIV WASHINGTON (US) | 2015-06-25 | — | — | US | disclosed |
| US-20140221647-A1 | PHENOXAZINE DERIVATIVES AND METHODS OF USE THEREOF | WASHINGTON UNIVERSITY | 2014-08-07 | — | — | US | disclosed |
| US-20140221647-A1 | PHENOXAZINE DERIVATIVES AND METHODS OF USE THEREOF | WASHINGTON UNIVERSITY | 2014-08-07 | — | — | US | disclosed |
| US-8735575-B2 | Phenoxazine derivatives and methods of use thereof | WASHINGTON UNIVERSITY (US) | 2014-05-27 | — | — | US | disclosed |
| US-8735575-B2 | Phenoxazine derivatives and methods of use thereof | WASHINGTON UNIVERSITY (US) | 2014-05-27 | — | — | US | disclosed |
| US-20120035359-A1 | PHENOXAZINE DERIVATIVES AND METHODS OF USE THEREOF | THE WASHINGTON UNIVERSITY (US) | 2012-02-09 | — | — | US | disclosed |
| US-20120035359-A1 | PHENOXAZINE DERIVATIVES AND METHODS OF USE THEREOF | THE WASHINGTON UNIVERSITY (US) | 2012-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140221647-A1 | PHENOXAZINE DERIVATIVES AND METHODS OF USE THEREOF | PPOX, CYP4Z1, PRDX2 | APP 3242/4885CYP1A2 12/4885NPC1 4157/4885 |
| US-20150175589-A1 | PHENOXAZINE DERIVATIVES AND METHODS OF USE THEREOF | PPOX, CYP4Z1, PRDX2 | APP 3242/4885CYP1A2 12/4885NPC1 4157/4885 |
| US-20240024490-A1 | BIFUNCTIONAL MOLECULES FOR SELECTIVE MODIFICATION OF TARGET SUBSTRATES | COASY, JMJD7, PTMS | APP 3721/4885CYP1A2 2469/4885NPC1 3771/4885 |
| US-20120035359-A1 | PHENOXAZINE DERIVATIVES AND METHODS OF USE THEREOF | PPOX, CYP4Z1, PRDX2 | APP 3242/4885CYP1A2 12/4885NPC1 4157/4885 |
| US-20230192904-A1 | BIFUNCTIONAL CHIMERIC MOLECULES FOR LABELING OF KINASES WITH TARGET BINDING MOIETIES AND METHODS OF USE THEREOF | ERBB2, ACP1, TK1 | APP 3490/4885CYP1A2 4154/4885NPC1 4064/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.