Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.56 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.56 |
| ▸ | BCL2 | P10415 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 7/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | NAMPT | P43490 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA7 | P43166 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10169289 | 0.83 | NOTUM (0.58) | HSP90AA1HSP90AB1BCL2SMN1; SMN2LMNA | |
| SCHEMBL10211721 | 0.82 | HPGD (0.56) | HPGDALDH1A1SMN1; SMN2NAMPTLMNA | |
| SCHEMBL29644419 | 0.82 | NFE2L2 (0.49) | HPGDALDH1A1SMN1; SMN2NAMPTLMNA | |
| SCHEMBL28739160 | 0.82 | NFE2L2 (0.49) | HPGDALDH1A1SMN1; SMN2NAMPTLMNA | |
| SCHEMBL3163275 | 0.81 | HPGD (0.53) | HSP90AA1HSP90AB1HPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL13051864 | 0.80 | HPGD (0.50) | HPGDALDH1A1SMN1; SMN2NAMPTLMNA | |
| SCHEMBL28739037 | 0.80 | ABHD6 (0.55) | HPGDALDH1A1SMN1; SMN2NAMPTLMNA | |
| SCHEMBL29644341 | 0.80 | ABHD6 (0.55) | HPGDALDH1A1SMN1; SMN2NAMPTLMNA | |
| SCHEMBL29644302 | 0.78 | KEAP1 (0.44) | HPGDALDH1A1SMN1; SMN2NAMPTLMNA | |
| SCHEMBL28739132 | 0.78 | KEAP1 (0.44) | HPGDALDH1A1SMN1; SMN2NAMPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8586751-B2 | Nicotinamide compounds useful as kinase modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2013-11-19 | — | — | US | disclosed |
| US-20120082702-A1 | NICOTINAMIDE COMPOUNDS USEFUL AS KINASE MODULATORS | BRISTOL-MEYERS SQUIBB COMPANY | 2012-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120082702-A1 | NICOTINAMIDE COMPOUNDS USEFUL AS KINASE MODULATORS | NADK, BTK, NAMPT | HSP90AA1 1609/4885HSP90AB1 967/4885BCL2 1808/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.