Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
| ▸ | KDM5A | P29375 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10170657 | 0.81 | ALDH1A1 (0.40) | ARSMN1; SMN2KDM5AALDH1A1CYP1A2 | |
| SCHEMBL12870164 | 0.78 | KDM4E (0.51) | ARSMN1; SMN2KDM4ELRRK2TSHR | |
| SCHEMBL10170655 | 0.77 | KDM4E (0.49) | SMN1; SMN2KDM4EKDM5AHPGDALDH1A1 | |
| SCHEMBL15093941 | 0.76 | GRM2 (0.43) | ARSMN1; SMN2KDM4ELRRK2TSHR | |
| SCHEMBL12051540 | 0.74 | NOS3 (0.43) | KDM4EMAPK1 | |
| SCHEMBL16224715 | 0.74 | GAA (0.50) | ARSMN1; SMN2KDM4EHPGDALDH1A1 | |
| SCHEMBL31657700 | 0.72 | AR (0.39) | ARSMN1; SMN2KDM4ETSHRALDH1A1 | |
| SCHEMBL4549701 | 0.72 | AR (0.39) | ARSMN1; SMN2KDM4ETSHRALDH1A1 | |
| SCHEMBL31253097 | 0.71 | HRH4 (0.45) | ARSMN1; SMN2KDM4ETSHRHPGD | |
| SCHEMBL1641172 | 0.71 | HRH4 (0.45) | ARSMN1; SMN2KDM4ETSHRHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8168668-B2 | Compounds | ASTRAZENECA AB (SE) | 2012-05-01 | — | — | US | disclosed |
| US-20100286202-A1 | New Compounds | ASTRAZENECA AB (SE) | 2010-11-11 | — | — | US | disclosed |
| US-7618993-B2 | Compounds | ASTRAZENECA AB (SE) | 2009-11-17 | — | — | US | disclosed |
| US-20080171770-A1 | Compounds | ASTRAZENECA AB (SE) | 2008-07-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100286202-A1 | New Compounds | REN, PCSK9, FURIN | AR 1556/4885SMN1; SMN2 3719/4885KDM4E 3569/4885 |
| US-20080171770-A1 | Compounds | REN, PCSK9, SLC10A1 | AR 980/4885SMN1; SMN2 3425/4885KDM4E 3792/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.