Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLRMT | O00411 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.33 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.32 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL882157 | 0.92 | POLRMT (0.45) | POLRMT | |
| SCHEMBL881457 | 0.86 | TMPRSS2 (0.34) | PIK3CDTMPRSS2RIPK1 | |
| SCHEMBL18697844 | 0.85 | POLRMT (0.38) | POLRMTTMPRSS2 | |
| SCHEMBL10149707 | 0.85 | POLRMT (0.38) | POLRMTTMPRSS2 | |
| SCHEMBL18697842 | 0.84 | FAP (0.33) | — | |
| SCHEMBL10142507 | 0.82 | POLRMT (0.38) | POLRMTTMPRSS2 | |
| SCHEMBL12454229 | 0.80 | POLRMT (0.38) | POLRMTPIK3CDTMPRSS2 | |
| SCHEMBL17215149 | 0.79 | PRMT5 (0.35) | PIK3CDTMPRSS2RIPK1 | |
| SCHEMBL18214657 | 0.79 | POLRMT (0.38) | POLRMTPIK3CDTMPRSS2 | |
| Gs-441326 SCHEMBL10149536 | 0.78 | POLRMT (0.47) | POLRMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012039787-A1 | 2' -FLUORO SUBSTITUTED CARBA-NUCLEOSIDE ANALOGS FOR ANTIVIRAL TREATMENT | GILEAD SCIENCES, INC. (US) | 2012-03-29 | — | — | WO | disclosed |