Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10160125 | 0.89 | MAPT (0.39) | KMT2ALMNAMAPTALDH1A1HPGD | |
| SCHEMBL359022 | 0.69 | THRB (0.43) | KMT2ALMNAMAPTALDH1A1PKM | |
| SCHEMBL10727958 | 0.67 | CYP3A4 (0.47) | KMT2ALMNAMAPTALDH1A1KDM4E | |
| SCHEMBL16920141 | 0.67 | ALDH1A1 (0.41) | KMT2ALMNAMAPTALDH1A1L3MBTL1 | |
| SCHEMBL3961361 | 0.65 | KMT2A (0.44) | KMT2ALMNAMAPTALDH1A1L3MBTL1 | |
| SCHEMBL16522671 | 0.64 | KMT2A (0.47) | KMT2ALMNAMAPTALDH1A1KDM4E | |
| SCHEMBL3968921 | 0.64 | ALDH1A1 (0.39) | KMT2ALMNAMAPTALDH1A1L3MBTL1 | |
| SCHEMBL27958738 | 0.64 | MAPT (0.42) | KMT2ALMNAMAPTALDH1A1KDM4E | |
| SCHEMBL17083920 | 0.64 | ALDH1A1 (0.64) | KMT2ALMNAMAPTALDH1A1KDM4E | |
| SCHEMBL16795576 | 0.64 | MMP8 (0.60) | KMT2ASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012022707-A1 | SUBSTITUTED HETEROARYL SPIROPYRROLIDINE MDM2 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-02-23 | — | — | WO | disclosed |