Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 7/20 | 0.54 |
| ▸ | MTNR1B | P49286 | 7/20 | 0.54 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | PRNP | P04156 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12446353 | 0.84 | MTNR1A (0.48) | MTNR1AMTNR1BMAOAMAOBRAB9A | |
| SCHEMBL554681 | 0.83 | MAOA (0.50) | MTNR1AMTNR1BMAOAMAOBFFAR1 | |
| SCHEMBL554680 | 0.83 | MAOA (0.50) | MTNR1AMTNR1BMAOAMAOBFFAR1 | |
| SCHEMBL10175130 | 0.81 | MTNR1A (0.58) | MTNR1AMTNR1BMAOAMAOBFFAR1 | |
| SCHEMBL7073776 | 0.81 | ALDH1A1 (0.51) | MTNR1AMTNR1BMAOAMAOBKCNA5 | |
| SCHEMBL10175212 | 0.77 | MTNR1A (0.50) | MTNR1AMTNR1BMAOAMAOBFFAR1 | |
| SCHEMBL11637955 | 0.77 | KCNA5 (0.44) | MTNR1AMTNR1BKCNA5RAB9AL3MBTL1 | |
| SCHEMBL14490649 | 0.76 | MAOA (0.68) | MTNR1AMTNR1BMAOAMAOBFFAR1 | |
| SCHEMBL6764561 | 0.75 | FFAR1 (0.61) | FFAR1RAB9AL3MBTL1SMN1; SMN2ALDH1A1 | |
| SCHEMBL10509525 | 0.75 | NPC1 (0.51) | MAOBKCNA5RAB9AALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160176906-A1 | Chemical Compounds | ASTRAZENECA AB (SE) | 2016-06-23 | — | — | US | disclosed |
| US-9248140-B2 | Chemical compounds | ASTRAZENECA AB (SE) | 2016-02-02 | — | — | US | disclosed |
| US-20150328239-A1 | Chemical Compounds | ASTRAZENECA AB (SE) | 2015-11-19 | — | — | US | disclosed |
| US-9018381-B2 | Chemical compounds | ASTRAZENECA AB (SE) | 2015-04-28 | — | — | US | disclosed |
| US-20130310344-A1 | N-ACYLSULFONAMIDE APOPTOSIS PROMOTERS | ASTRAZENECA AB (UK) | 2013-11-21 | — | — | US | disclosed |
| US-20120035134-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2012-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120035134-A1 | CHEMICAL COMPOUNDS | BCL2, BCL2L1, BAX | MTNR1A 2899/4885MTNR1B 1836/4885MAOA 1944/4885 |
| US-20150328239-A1 | Chemical Compounds | BCL2, BCL2L1, BAX | MTNR1A 2899/4885MTNR1B 1836/4885MAOA 1944/4885 |
| US-20160176906-A1 | Chemical Compounds | BCL2, BCL2L1, BAX | MTNR1A 2899/4885MTNR1B 1836/4885MAOA 1944/4885 |
| US-20130310344-A1 | N-ACYLSULFONAMIDE APOPTOSIS PROMOTERS | BCL2, BAX, BCLAF1 | MTNR1A 3368/4885MTNR1B 2617/4885MAOA 3289/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.