Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 15/20 | 0.60 |
| ▸ | CYP11B1 | P15538 | 9/20 | 0.60 |
| ▸ | DPP4 | P27487 | 1/20 | 0.51 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.43 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.42 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10175592 | 0.82 | CYP11B2 (0.76) | CYP11B2CYP11B1 | |
| SCHEMBL17896769 | 0.81 | CYP11B2 (0.48) | CYP11B2CYP11B1DPP4DPP8MAPT | |
| SCHEMBL10176205 | 0.81 | CYP11B2 (0.56) | CYP11B2CYP11B1 | |
| SCHEMBL10175459 | 0.81 | CYP11B2 (0.56) | CYP11B2CYP11B1 | |
| SCHEMBL17896700 | 0.80 | CYP11B2 (0.62) | CYP11B2CYP11B1DPP4DPP8ATM | |
| SCHEMBL17896705 | 0.78 | CYP11B2 (0.54) | CYP11B2CYP11B1DPP4DPP8 | |
| SCHEMBL463351 | 0.78 | CYP11B2 (0.67) | CYP11B2CYP11B1 | |
| SCHEMBL10175451 | 0.78 | CYP11B2 (0.63) | CYP11B2CYP11B1 | |
| SCHEMBL17897057 | 0.76 | CYP11B2 (0.52) | CYP11B2CYP11B1 | |
| SCHEMBL17896707 | 0.76 | CYP11B2 (0.52) | CYP11B2CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9382226-B2 | Aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-07-05 | — | — | US | disclosed |
| US-9382226-B2 | Aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-07-05 | — | — | US | disclosed |
| WO-2012012478-A1 | ALDOSTERONE SYNTHASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-01-26 | — | — | WO | disclosed |