Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 11/20 | 0.51 |
| ▸ | CYP11B1 | P15538 | 7/20 | 0.51 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.36 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10175117 | 0.84 | CYP11B2 (0.67) | CYP11B2CYP11B1 | |
| SCHEMBL10176205 | 0.83 | CYP11B2 (0.56) | CYP11B2CYP11B1PIK3CGTLR7 | |
| SCHEMBL10175459 | 0.83 | CYP11B2 (0.56) | CYP11B2CYP11B1 | |
| SCHEMBL17896704 | 0.81 | CYP11B2 (0.49) | CYP11B2CYP11B1SSTR5TLR7NPY5R | |
| SCHEMBL17896705 | 0.81 | CYP11B2 (0.54) | CYP11B2CYP11B1TLR7 | |
| SCHEMBL462661 | 0.81 | CYP11B2 (0.46) | CYP11B2CYP11B1SSTR5TLR7 | |
| SCHEMBL17897057 | 0.79 | CYP11B2 (0.52) | CYP11B2CYP11B1 | |
| SCHEMBL17896707 | 0.79 | CYP11B2 (0.52) | CYP11B2CYP11B1 | |
| SCHEMBL10175146 | 0.79 | CYP11B2 (0.67) | CYP11B2CYP11B1 | |
| SCHEMBL17896609 | 0.77 | CYP11B2 (0.48) | CYP11B2CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9382226-B2 | Aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-07-05 | — | — | US | claimed |
| US-9382226-B2 | Aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-07-05 | — | — | US | disclosed |
| US-9382226-B2 | Aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-07-05 | — | — | US | disclosed |
| WO-2012012478-A1 | ALDOSTERONE SYNTHASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-01-26 | — | — | WO | disclosed |