Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 8/20 | 0.49 |
| ▸ | CYP11B1 | P15538 | 5/20 | 0.49 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.40 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 7/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17896600 | 0.84 | CYP11B2 (0.45) | CYP11B2CYP11B1TLR7CHRNB2CHRNB4 | |
| SCHEMBL17896702 | 0.83 | CYP11B2 (0.41) | CYP11B2CYP11B1 | |
| SCHEMBL10175455 | 0.81 | CYP11B2 (0.51) | CYP11B2CYP11B1SSTR5NPY5RTLR7 | |
| SCHEMBL17896699 | 0.81 | PTGS2 (0.39) | CYP11B2CYP11B1TLR7 | |
| SCHEMBL10175146 | 0.80 | CYP11B2 (0.67) | CYP11B2CYP11B1 | |
| SCHEMBL17896703 | 0.79 | CYP11B1 (0.50) | CYP11B2CYP11B1 | |
| SCHEMBL17896700 | 0.75 | CYP11B2 (0.62) | CYP11B2CYP11B1 | |
| SCHEMBL17896609 | 0.73 | CYP11B2 (0.48) | CYP11B2CYP11B1 | |
| SCHEMBL460559 | 0.72 | CYP11B2 (0.46) | CYP11B2CYP11B1SSTR5 | |
| SCHEMBL462661 | 0.72 | CYP11B2 (0.46) | CYP11B2CYP11B1SSTR5TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9382226-B2 | Aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-07-05 | — | — | US | disclosed |
| US-9382226-B2 | Aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-07-05 | — | — | US | disclosed |