Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 13/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 9/20 | 0.43 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.39 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | DHFR | P00374 | 1/20 | 0.37 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL458763 | 0.87 | CYP11B2 (0.43) | CYP11B2CYP11B1ALOX5APUSP2HTT | |
| SCHEMBL17896749 | 0.84 | CYP11B2 (0.45) | CYP11B2CYP11B1ALOX5APUSP2HTT | |
| SCHEMBL17896747 | 0.81 | PTGS2 (0.46) | CYP11B2CYP11B1ALOX5APUSP2HTT | |
| SCHEMBL17896746 | 0.80 | CYP11B2 (0.42) | CYP11B2CYP11B1ALOX5APUSP2HTT | |
| SCHEMBL458936 | 0.80 | CYP11B2 (0.44) | CYP11B2CYP11B1ALOX5APUSP2HTT | |
| SCHEMBL10175792 | 0.70 | CYP11B2 (0.46) | CYP11B2CYP11B1ALOX5APUSP2HTT | |
| SCHEMBL17896751 | 0.70 | MAPT (0.49) | CYP11B2CYP11B1CYP19A1LMNAPOLB | |
| SCHEMBL17896748 | 0.68 | USP2 (0.47) | CYP11B2CYP11B1ALOX5APUSP2HTT | |
| SCHEMBL459209 | 0.68 | PTGS2 (0.48) | CYP11B2CYP11B1ALOX5APUSP2HTT | |
| SCHEMBL17896752 | 0.67 | CYP11B1 (0.44) | CYP11B2CYP11B1USP2HTTCYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9382226-B2 | Aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-07-05 | — | — | US | disclosed |
| US-9382226-B2 | Aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-07-05 | — | — | US | disclosed |
| WO-2012012478-A1 | ALDOSTERONE SYNTHASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-01-26 | — | — | WO | disclosed |