Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.70 |
| ▸ | HTT | P42858 | 1/20 | 0.70 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.70 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.70 |
| ▸ | CYP11B2 | P19099 | 12/20 | 0.62 |
| ▸ | CYP11B1 | P15538 | 10/20 | 0.62 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | G6PD | P11413 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALPG | P10696 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10175606 | 0.83 | CYP11B2 (0.60) | USP2HTTNCOA1NCOA3CYP11B2 | |
| SCHEMBL17896748 | 0.82 | USP2 (0.47) | USP2HTTNCOA1NCOA3CYP11B2 | |
| SCHEMBL10175131 | 0.81 | USP2 (0.65) | USP2HTTNCOA1NCOA3CYP11B2 | |
| SCHEMBL10175607 | 0.80 | CYP11B2 (0.49) | USP2HTTNCOA1NCOA3CYP11B2 | |
| SCHEMBL17896625 | 0.80 | CYP11B2 (0.62) | USP2HTTNCOA1NCOA3CYP11B2 | |
| SCHEMBL10175792 | 0.80 | CYP11B2 (0.46) | USP2HTTNCOA1NCOA3CYP11B2 | |
| SCHEMBL17883790 | 0.78 | USP2 (0.63) | USP2HTTNCOA1NCOA3CYP11B2 | |
| SCHEMBL10176165 | 0.77 | CYP11B2 (1.00) | USP2HTTNCOA1NCOA3CYP11B2 | |
| SCHEMBL17896749 | 0.77 | CYP11B2 (0.45) | USP2HTTNCOA1NCOA3CYP11B2 | |
| SCHEMBL10176229 | 0.76 | CYP11B2 (0.74) | CYP11B2CYP11B1HTR2BHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9382226-B2 | Aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-07-05 | — | — | US | disclosed |
| US-9382226-B2 | Aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-07-05 | — | — | US | disclosed |
| WO-2012012478-A1 | ALDOSTERONE SYNTHASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-01-26 | — | — | WO | disclosed |