Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 10/20 | 0.49 |
| ▸ | CYP11B1 | P15538 | 8/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.43 |
| ▸ | G6PD | P11413 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.43 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.43 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.43 |
| ▸ | PRNP | P04156 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.43 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17896753 | 0.89 | CYP11B2 (0.50) | CYP11B2CYP11B1KMT2AMEN1ATM | |
| SCHEMBL10175606 | 0.83 | CYP11B2 (0.60) | CYP11B2CYP11B1KMT2AMEN1ATM | |
| SCHEMBL17896625 | 0.80 | CYP11B2 (0.62) | CYP11B2CYP11B1KMT2AMEN1USP2 | |
| SCHEMBL10175792 | 0.80 | CYP11B2 (0.46) | CYP11B2CYP11B1RAD51HTR2BHTR6 | |
| SCHEMBL458936 | 0.80 | CYP11B2 (0.44) | CYP11B2CYP11B1RAD51HTR2BHTR6 | |
| SCHEMBL10176228 | 0.80 | USP2 (0.70) | CYP11B2CYP11B1KMT2AHTR2BHTR6 | |
| SCHEMBL17896745 | 0.79 | PTGS2 (0.51) | CYP11B2CYP11B1USP2HTTNCOA1 | |
| SCHEMBL10176229 | 0.79 | CYP11B2 (0.74) | CYP11B2CYP11B1HTR2BHTR6 | |
| SCHEMBL17896750 | 0.78 | CYP11B2 (0.43) | CYP11B2CYP11B1RAD51HTR2BHTR6 | |
| SCHEMBL17896748 | 0.78 | USP2 (0.47) | CYP11B2CYP11B1KMT2ARAD51HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9382226-B2 | Aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-07-05 | — | — | US | disclosed |
| US-9382226-B2 | Aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-07-05 | — | — | US | disclosed |
| WO-2012012478-A1 | ALDOSTERONE SYNTHASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-01-26 | — | — | WO | disclosed |