Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 7/20 | 0.60 |
| ▸ | CYP11B1 | P15538 | 6/20 | 0.60 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | NAMPT | P43490 | 1/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.46 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.46 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30663914 | 0.89 | CYP11B2 (0.71) | CYP11B2CYP11B1ATMUSP2HTT | |
| SCHEMBL8209154 | 0.89 | CYP11B2 (0.71) | CYP11B2CYP11B1ATMUSP2HTT | |
| SCHEMBL337983 | 0.84 | ALDH1A1 (0.58) | ATMNPC1ALDH1A1TP53MAPT | |
| SCHEMBL10176167 | 0.83 | CYP11B2 (0.80) | CYP11B2CYP11B1ATMNAMPTUSP2 | |
| SCHEMBL10175607 | 0.83 | CYP11B2 (0.49) | CYP11B2CYP11B1ATMMAPTUSP2 | |
| SCHEMBL10176218 | 0.83 | CYP11B2 (0.60) | CYP11B2CYP11B1ATMNPC1ALDH1A1 | |
| SCHEMBL17896625 | 0.83 | CYP11B2 (0.62) | CYP11B2CYP11B1ALDH1A1MAPTTSHR | |
| SCHEMBL10176228 | 0.83 | USP2 (0.70) | CYP11B2CYP11B1ALDH1A1TP53MAPT | |
| SCHEMBL10175792 | 0.83 | CYP11B2 (0.46) | CYP11B2CYP11B1NPC1RAB9AUSP2 | |
| SCHEMBL17896623 | 0.82 | MEN1 (0.62) | ATMNPC1ALDH1A1TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9382226-B2 | Aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-07-05 | — | — | US | disclosed |
| US-9382226-B2 | Aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-07-05 | — | — | US | disclosed |
| WO-2012012478-A1 | ALDOSTERONE SYNTHASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-01-26 | — | — | WO | disclosed |