Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SDHB | P21912 | 1/20 | 0.42 |
| ▸ | USP1 | O94782 | 5/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 4/20 | 0.38 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7469586 | 0.90 | PTGS2 (0.46) | SDHBUSP1PTGS2PTGS1BRD4 | |
| SCHEMBL9940255 | 0.86 | NR1H2 (0.48) | SDHBUSP1PTGS2PTGS1BRD4 | |
| SCHEMBL13100054 | 0.82 | PTGS2 (0.61) | SDHBPTGS2PTGS1 | |
| SCHEMBL16660862 | 0.81 | DGAT1 (0.58) | SDHBUSP1PTGS2PTGS1BRD4 | |
| SCHEMBL29194233 | 0.78 | DRD2 (0.47) | SDHBUSP1DGAT1SMN1; SMN2 | |
| SCHEMBL27914819 | 0.76 | BRD4 (0.46) | BRD4SMN1; SMN2 | |
| SCHEMBL11622203 | 0.75 | PTGS2 (0.51) | USP1PTGS2PTGS1DGAT1SMN1; SMN2 | |
| SCHEMBL9940251 | 0.74 | DGAT1 (0.55) | DGAT1 | |
| SCHEMBL10914894 | 0.74 | ESR1 (0.39) | SDHBUSP1BRD4DGAT1 | |
| SCHEMBL9940249 | 0.72 | DGAT1 (0.55) | SDHBUSP1BRD4DGAT1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012081736-A1 | CONTINUOUS ARYCYCLIC COMPOUND | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2012-06-21 | — | — | WO | disclosed |