SCHEMBL10179290

SCHEMBL10179290

O=C(O)N1CCC(c2cnc(CO)c(Cl)c2)CC1

nearest known ligand 0.41

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
EGLN1 Q9GZT9 16/20 0.41
SPR P35270 2/20 0.38
GRM5 P41594 1/20 0.37
GAA P10253 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10181235 0.90 EGLN1 (0.41) EGLN1SPR
SCHEMBL1578026 0.84 EGLN1 (0.41) EGLN1
SCHEMBL10180121 0.84 EGLN1 (0.41) EGLN1GAA
SCHEMBL10179150 0.82 DDB1 (0.48) GAA
SCHEMBL14142288 0.79 MAPT (0.39) EGLN1GAA
SCHEMBL1577922 0.77 GPR119 (0.45) EGLN1
SCHEMBL1577753 0.74 KDM4E (0.42) EGLN1
SCHEMBL10181204 0.72 DDB1 (0.48) GAA
SCHEMBL10180087 0.72 CCR2 (0.38)
SCHEMBL15972489 0.72 MAPK1 (0.40) EGLN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120245344-A1 GPR119 AGONIST NIPPON CHEMIPHAR CO., LTD. (JP) 2012-09-27 US disclosed
EP-2474540-A1 GPR119 AGONIST Nippon Chemiphar Co., Ltd. (JP) 2012-07-11 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120245344-A1 GPR119 AGONIST GPR119, GPR4, GPR55 EGLN1 1443/4885SPR 3618/4885GRM5 457/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.