Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | MAPT | P10636 | 5/20 | 0.35 |
| ▸ | MEN1 | O00255 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | PKM | P14618 | 2/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12947032 | 0.86 | ALDH1A1 (0.35) | PIK3CDALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL10180469 | 0.81 | MEN1 (0.41) | ALDH1A1MAPTMEN1KMT2ALMNA | |
| SCHEMBL3460273 | 0.74 | BRAF (0.38) | PIK3CDALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL10180124 | 0.73 | MEN1 (0.46) | ALDH1A1MAPTMEN1KMT2ALMNA | |
| SCHEMBL3460271 | 0.72 | BRAF (0.39) | PIK3CDALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL10180924 | 0.71 | MAPK8 (0.42) | ADORA1 | |
| SCHEMBL965134 | 0.69 | ADORA1 (0.38) | ADORA1 | |
| SCHEMBL10181000 | 0.69 | MEN1 (0.42) | ALDH1A1MAPTMEN1KMT2ALMNA | |
| SCHEMBL10180897 | 0.67 | HPGD (0.42) | PIK3CDALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL10180972 | 0.66 | LMNA (0.40) | ALDH1A1MAPTMEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678168-B1 | P70S6 KINASE MODULATORS AND METHOD OF USE | EXELIXIS INC (US) | 2012-07-11 | — | — | EP | claimed |