Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 11/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | AKT1 | P31749 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12946857 | 0.94 | TRPV4 (0.44) | TRPV4THRBLCKKDREPHX2 | |
| SCHEMBL10180028 | 0.93 | MAPK8 (0.45) | TRPV4THRBEPHX2AKT1LMNA | |
| SCHEMBL10180493 | 0.88 | TRPV4 (0.42) | TRPV4THRBEPHX2AKT1LMNA | |
| SCHEMBL12946985 | 0.87 | MAPK8 (0.45) | TRPV4THRBLCKKDREPHX2 | |
| SCHEMBL10327267 | 0.86 | LMNA (0.46) | TRPV4THRBLCKKDREPHX2 | |
| SCHEMBL10181524 | 0.85 | TRPV4 (0.46) | TRPV4EPHX2KMT2ASLC6A2HTR2A | |
| SCHEMBL3460495 | 0.84 | KDM4E (0.38) | LMNAKMT2A | |
| SCHEMBL12946845 | 0.83 | TRPV4 (0.44) | TRPV4THRBEPHX2AKT1LMNA | |
| SCHEMBL3460056 | 0.82 | SMN1; SMN2 (0.40) | LMNAKMT2ABRAF | |
| SCHEMBL10181357 | 0.80 | TRPV4 (0.47) | TRPV4EPHX2KMT2AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678168-B1 | P70S6 KINASE MODULATORS AND METHOD OF USE | EXELIXIS INC (US) | 2012-07-11 | — | — | EP | claimed |