Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CTSA | P10619 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3405403 | 0.84 | KDM4E (0.55) | CYP1A2ALDH1A1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL5092353 | 0.84 | CYP1A2 (0.57) | CYP1A2ALDH1A1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL984078 | 0.82 | CYP1A2 (0.50) | CYP1A2ALDH1A1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL577637 | 0.82 | POLB (0.53) | CYP1A2ALDH1A1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL8404026 | 0.82 | ALDH1A1 (0.64) | CYP1A2ALDH1A1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL12883191 | 0.79 | CYP1A2 (0.47) | CYP1A2ALDH1A1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL30501799 | 0.79 | ALDH1A1 (0.50) | CYP1A2ALDH1A1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL8069600 | 0.77 | NPC1 (0.46) | CYP1A2ALDH1A1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL1720041 | 0.77 | ALDH1A1 (0.49) | CYP1A2ALDH1A1KDM4ESMN1; SMN2CTSA | |
| SCHEMBL21884142 | 0.77 | CYP1A2 (0.50) | CYP1A2ALDH1A1KDM4ELMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2474536-B1 | PROCESS FOR PREPARATION OF PYRIMIDINYLACETONITRILE DERIVATIVES AND INTERMEDIATES FOR SYNTHESIS THEREOF | IHARA CHEMICAL IND CO (JP) | 2014-06-25 | — | — | EP | disclosed |
| EP-2674420-A1 | METHOD FOR PRODUCING AMINOPHENYL PYRIMIDINYL ALCOHOL DERIVATIVE, AND SYNTHESIS INTERMEDIATE THEREOF | Ihara Chemical Industry Co., Ltd. (JP) | 2013-12-18 | — | — | EP | disclosed |
| US-20120178931-A1 | PROCESS FOR PREPARATION OF PYRIMIDINYLACETONITRILE DERIVATIVES AND INTERMEDIATES FOR SYNTHESIS THEREOF | IHARA CHEMICAL INDUSTRY CO., LTD (JP) | 2012-07-12 | — | — | US | disclosed |
| EP-2474536-A1 | PROCESS FOR PREPARATION OF PYRIMIDINYLACETONITRILE DERIVATIVES AND INTERMEDIATES FOR SYNTHESIS THEREOF | Ihara Chemical Industry Co., Ltd. (JP) | 2012-07-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120178931-A1 | PROCESS FOR PREPARATION OF PYRIMIDINYLACETONITRILE DERIVATIVES AND INTERMEDIATES FOR SYNTHESIS THEREOF | DPYD, UMPS, PNP | CYP1A2 58/4885ALDH1A1 238/4885KDM4E 809/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.