SCHEMBL21884142

SCHEMBL21884142

COc1cc(OC)nc(C(=O)NN)n1

nearest known ligand 0.50

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.50
ALDH1A1 P00352 5/20 0.48
KDM4E B2RXH2 4/20 0.48
SMN1; SMN2 Q16637 3/20 0.47
CTSA P10619 1/20 0.47
KMT2A Q03164 3/20 0.46
MEN1 O00255 2/20 0.46
GAA P10253 2/20 0.46
MCL1 Q07820 1/20 0.46
L3MBTL1 Q9Y468 1/20 0.46
P2RX7 Q99572 1/20 0.44
CA1 P00915 1/20 0.43
CA2 P00918 1/20 0.43
LMNA P02545 2/20 0.41
POLB P06746 2/20 0.41
CTSD P07339 1/20 0.41
TDP1 Q9NUW8 1/20 0.41
MAPT P10636 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20931377 0.79 P2RX7 (0.52) CYP1A2ALDH1A1KDM4ESMN1; SMN2CTSA
SCHEMBL577637 0.78 POLB (0.53) CYP1A2ALDH1A1KDM4ESMN1; SMN2GAA
SCHEMBL8404026 0.78 ALDH1A1 (0.64) CYP1A2ALDH1A1KDM4ESMN1; SMN2CTSA
SCHEMBL10181023 0.77 CYP1A2 (0.53) CYP1A2ALDH1A1KDM4ESMN1; SMN2CTSA
SCHEMBL9685817 0.77 CYP1A2 (0.42) CYP1A2ALDH1A1KDM4ESMN1; SMN2CTSA
SCHEMBL5092353 0.75 CYP1A2 (0.57) CYP1A2ALDH1A1KDM4ESMN1; SMN2L3MBTL1
SCHEMBL3405403 0.75 KDM4E (0.55) CYP1A2ALDH1A1KDM4ESMN1; SMN2LMNA
SCHEMBL18246199 0.75 P2RX7 (0.44) CYP1A2ALDH1A1KDM4ESMN1; SMN2CTSA
SCHEMBL2896733 0.75 LMNA (0.65) CYP1A2ALDH1A1KDM4ESMN1; SMN2CTSA
SCHEMBL12883191 0.74 CYP1A2 (0.47) CYP1A2ALDH1A1KDM4ESMN1; SMN2CTSA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020058062-A1 HERBICIDALLY ACTIVE SUBSTITUTED PHENYLPYRIMIDINE HYDRAZIDES BAYER AKTIENGESELLSCHAFT (DE) 2020-03-26 WO disclosed