Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 4/20 | 0.39 |
| ▸ | NEK2 | P51955 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 7/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CKS1B | P61024 | 1/20 | 0.32 |
| ▸ | SKP1 | P63208 | 1/20 | 0.32 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 2/20 | 0.32 |
| ▸ | BCR | P11274 | 2/20 | 0.32 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.32 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.32 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1018735 | 0.86 | ABL1 (0.46) | HCRTR2SMN1; SMN2ABL1BCR | |
| SCHEMBL1018020 | 0.81 | ROCK2 (0.37) | PDE10AHCRTR2CKS1BSKP1SKP2 | |
| SCHEMBL4307476 | 0.80 | SMN1; SMN2 (0.36) | NEK2HCRTR2SMN1; SMN2ABL1BCR | |
| SCHEMBL1021392 | 0.78 | ENPP1 (0.33) | CKS1BSKP1SKP2SIRT2SIRT1 | |
| SCHEMBL4307471 | 0.77 | CKS1B (0.41) | CKS1BSKP1SKP2SIRT2SIRT1 | |
| SCHEMBL12083122 | 0.76 | CKS1B (0.53) | CKS1BSKP1SKP2SIRT2SIRT1 | |
| SCHEMBL27912561 | 0.75 | PDE10A (0.44) | CNR2PDE10AHCRTR2ABL1BCR | |
| SCHEMBL1018116 | 0.73 | ABL1 (0.39) | CNR2NEK2HCRTR2SMN1; SMN2CKS1B | |
| SCHEMBL343114 | 0.71 | CRHR1 (0.33) | — | |
| SCHEMBL2521770 | 0.70 | PIM1 (0.36) | CNR2NEK2SMN1; SMN2CKS1BSKP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2271631-A2 | INHIBITORS OF PROTEIN KINASES | Portola Pharmaceuticals, Inc. (US) | 2011-01-12 | — | — | EP | disclosed |