Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 2/20 | 0.33 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.31 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.30 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.30 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL342898 | 0.85 | CRHR1 (0.33) | CRHR1NR3C1MAPK1ADORA3ADORA1 | |
| SCHEMBL343925 | 0.85 | CRHR1 (0.33) | CRHR1NR3C1MAPK1ADORA3ADORA1 | |
| SCHEMBL342899 | 0.85 | CRHR1 (0.33) | CRHR1NR3C1MAPK1ADORA3ADORA1 | |
| SCHEMBL342888 | 0.82 | ADORA3 (0.35) | CRHR1KAT2BNR3C1MAPK1ADORA3 | |
| SCHEMBL28651973 | 0.80 | GRM2 (0.34) | CRHR1KAT2BNR3C1ADORA3ADORA1 | |
| SCHEMBL344026 | 0.80 | JAK1 (0.42) | — | |
| SCHEMBL342887 | 0.77 | MITF (0.38) | CRHR1NR3C1ADORA3ADORA1 | |
| SCHEMBL342889 | 0.77 | MITF (0.38) | CRHR1NR3C1ADORA3ADORA1 | |
| SCHEMBL342907 | 0.77 | JAK1 (0.46) | — | |
| SCHEMBL343335 | 0.77 | AURKA (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120015963-A1 | NOVEL PYRAZOLO[3,4-d]PYRIMIDINE COMPOUNDS | ABBOTT LABORATORIES (US) | 2012-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120015963-A1 | NOVEL PYRAZOLO[3,4-d]PYRIMIDINE COMPOUNDS | CHUK, MAP2K2, CDK3 | CRHR1 1832/4885KAT2B 3469/4885S1PR1 165/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.