Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 14/20 | 0.46 |
| ▸ | BCR | P11274 | 14/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1018117 | 0.86 | CNR2 (0.39) | ABL1BCRHCRTR2SMN1; SMN2 | |
| SCHEMBL1018020 | 0.82 | ROCK2 (0.37) | HCRTR2 | |
| SCHEMBL4304308 | 0.80 | ABL1 (0.52) | ABL1BCROPRK1HCRTR2SMN1; SMN2 | |
| SCHEMBL17700131 | 0.79 | ABL1 (0.52) | ABL1BCR | |
| SCHEMBL1021392 | 0.78 | ENPP1 (0.33) | — | |
| SCHEMBL4304306 | 0.77 | ABL1 (0.48) | ABL1BCR | |
| SCHEMBL12082925 | 0.75 | CKS1B (0.54) | ABL1BCR | |
| SCHEMBL27930644 | 0.74 | ABL1 (0.46) | ABL1BCROPRK1 | |
| SCHEMBL1018733 | 0.72 | ABL1 (0.51) | ABL1BCRHCRTR2 | |
| SCHEMBL16701397 | 0.72 | ABL1 (0.59) | ABL1BCRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2271631-A2 | INHIBITORS OF PROTEIN KINASES | Portola Pharmaceuticals, Inc. (US) | 2011-01-12 | — | — | EP | disclosed |