Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10183271 | 0.85 | MAPT (0.42) | TP53MAPTPOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL10183925 | 0.82 | TP53 (0.41) | TP53MAPTKDM4EPOLBHTT | |
| SCHEMBL10183670 | 0.81 | TRPM8 (0.41) | POLBNPSR1OPRM1OPRK1OPRL1 | |
| SCHEMBL10183302 | 0.79 | PTAFR (0.41) | MAPTPOLBHTTALDH1A1SMN1; SMN2 | |
| SCHEMBL10184173 | 0.78 | OPRM1 (0.37) | KDM4EKMT2AOPRM1OPRK1OPRL1 | |
| SCHEMBL10183929 | 0.77 | CHRM2 (0.43) | MAPTKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL10185835 | 0.70 | TSHR (0.38) | MAPTPOLBHTTALDH1A1SMN1; SMN2 | |
| SCHEMBL15119061 | 0.68 | IDH1 (0.47) | KDM4EHTTMEN1KMT2ALMNA | |
| SCHEMBL10184164 | 0.66 | ACKR3 (0.35) | TP53MAPTOPRM1OPRK1OPRL1 | |
| SCHEMBL10183227 | 0.65 | MAPT (0.42) | TP53MAPTKDM4EPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012009678-A1 | THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHOD OF USE | AGIOS PHARMACEUTICALS, INC. (US) | 2012-01-19 | — | — | WO | disclosed |