Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | CCKBR | P32239 | 1/20 | 0.40 |
| ▸ | MC4R | P32245 | 1/20 | 0.40 |
| ▸ | MC5R | P33032 | 1/20 | 0.40 |
| ▸ | MC3R | P41968 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10183722 | 0.85 | TP53 (0.41) | MAPTMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL10183670 | 0.81 | TRPM8 (0.41) | OPRM1OPRK1OPRL1NPSR1POLB | |
| SCHEMBL10183227 | 0.80 | MAPT (0.42) | MAPTMEN1KMT2AMC4RMC5R | |
| SCHEMBL10184173 | 0.78 | OPRM1 (0.37) | KMT2ACCKBROPRM1OPRK1OPRL1 | |
| SCHEMBL10183929 | 0.76 | CHRM2 (0.43) | MAPTMEN1KMT2AALDH1A1OPRM1 | |
| SCHEMBL10183302 | 0.76 | PTAFR (0.41) | MAPTALDH1A1SMN1; SMN2LMNAPKM | |
| SCHEMBL10183922 | 0.74 | HTR1A (0.36) | MAPTMEN1KMT2AMC4RMC5R | |
| SCHEMBL15119052 | 0.68 | IDH1 (0.47) | MEN1KMT2ALMNANPSR1 | |
| SCHEMBL10185583 | 0.67 | OPRM1 (0.35) | MAPTMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL10183925 | 0.67 | TP53 (0.41) | MAPTMEN1KMT2AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012009678-A1 | THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHOD OF USE | AGIOS PHARMACEUTICALS, INC. (US) | 2012-01-19 | — | — | WO | disclosed |