Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | AGER | Q15109 | 4/20 | 0.35 |
| ▸ | APAF1 | O14727 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.34 |
| ▸ | FDPS | P14324 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10183302 | 0.73 | PTAFR (0.41) | LMNAHTTOPRM1OPRK1OPRL1 | |
| SCHEMBL10185523 | 0.73 | IDH1 (0.36) | OPRM1OPRK1OPRL1ALDH1A1 | |
| SCHEMBL10184173 | 0.72 | OPRM1 (0.37) | OPRM1OPRK1OPRL1 | |
| SCHEMBL10183722 | 0.70 | TP53 (0.41) | TSHRLMNAHTTNPSR1OPRM1 | |
| SCHEMBL10183670 | 0.68 | TRPM8 (0.41) | NPSR1OPRM1OPRK1OPRL1POLB | |
| SCHEMBL10183290 | 0.68 | IDH1 (0.50) | TSHRLMNAHTTNPSR1HRH3 | |
| SCHEMBL10183929 | 0.67 | CHRM2 (0.43) | TSHROPRM1OPRK1OPRL1MAPT | |
| SCHEMBL10183271 | 0.66 | MAPT (0.42) | LMNANPSR1OPRM1OPRK1OPRL1 | |
| SCHEMBL10185869 | 0.63 | OPRM1 (0.40) | LMNAOPRM1OPRK1OPRL1MAPT | |
| SCHEMBL10185837 | 0.62 | OPRM1 (0.34) | OPRM1OPRK1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012009678-A1 | THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHOD OF USE | AGIOS PHARMACEUTICALS, INC. (US) | 2012-01-19 | — | — | WO | disclosed |