Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 3/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | IDH1 | O75874 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TNKS | O95271 | 1/20 | 0.33 |
| ▸ | WNT3A | P56704 | 1/20 | 0.33 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10185544 | 0.93 | OPRM1 (0.40) | OPRM1OPRD1OPRK1POLBMAPK1 | |
| SCHEMBL10185926 | 0.92 | OPRM1 (0.39) | OPRM1OPRD1OPRK1POLBMAPK1 | |
| SCHEMBL10183666 | 0.92 | OPRM1 (0.39) | OPRM1OPRD1OPRK1POLBMAPK1 | |
| SCHEMBL10183314 | 0.84 | CCKBR (0.37) | OPRM1OPRD1OPRK1POLBMAPK1 | |
| SCHEMBL10184153 | 0.82 | OPRM1 (0.39) | OPRM1OPRD1OPRK1POLBSIGMAR1 | |
| SCHEMBL10185945 | 0.82 | OPRM1 (0.39) | OPRM1OPRD1OPRK1POLBSIGMAR1 | |
| SCHEMBL10184095 | 0.82 | TP53 (0.41) | OPRM1OPRD1OPRK1 | |
| SCHEMBL10183904 | 0.81 | OPRM1 (0.38) | OPRM1OPRD1OPRK1POLBMAPK1 | |
| SCHEMBL10184154 | 0.81 | POLB (0.39) | OPRM1OPRD1OPRK1POLBMAPT | |
| SCHEMBL10183975 | 0.80 | POLB (0.37) | OPRM1OPRD1OPRK1POLBMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012009678-A1 | THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHOD OF USE | AGIOS PHARMACEUTICALS, INC. (US) | 2012-01-19 | — | — | WO | disclosed |