Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 4/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10185544 | 0.84 | OPRM1 (0.40) | TP53LMNAOPRM1OPRD1OPRK1 | |
| SCHEMBL10185926 | 0.83 | OPRM1 (0.39) | TP53LMNAOPRM1OPRD1OPRK1 | |
| SCHEMBL10183666 | 0.83 | OPRM1 (0.39) | TP53LMNAOPRM1OPRD1OPRK1 | |
| SCHEMBL10183767 | 0.82 | OPRM1 (0.39) | OPRM1OPRD1OPRK1 | |
| SCHEMBL10183314 | 0.77 | CCKBR (0.37) | OPRM1OPRD1OPRK1 | |
| SCHEMBL10185945 | 0.75 | OPRM1 (0.39) | TP53OPRM1OPRD1OPRK1 | |
| SCHEMBL10183904 | 0.74 | OPRM1 (0.38) | OPRM1OPRD1OPRK1 | |
| SCHEMBL10184154 | 0.74 | POLB (0.39) | MEN1KMT2AOPRM1OPRD1OPRK1 | |
| SCHEMBL10184153 | 0.74 | OPRM1 (0.39) | OPRM1OPRD1OPRK1 | |
| SCHEMBL10183975 | 0.73 | POLB (0.37) | TP53MEN1KMT2AOPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012009678-A1 | THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHOD OF USE | AGIOS PHARMACEUTICALS, INC. (US) | 2012-01-19 | — | — | WO | disclosed |