Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.31 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.30 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.30 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.30 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.30 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.30 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10183975 | 0.80 | POLB (0.37) | MAPK1RAB9APOLBMAPTALDH1A1 | |
| SCHEMBL10185544 | 0.72 | OPRM1 (0.40) | MAPK1RAB9APOLBMAPTALDH1A1 | |
| SCHEMBL10185926 | 0.72 | OPRM1 (0.39) | MAPK1RAB9APOLBMAPTALDH1A1 | |
| SCHEMBL10183666 | 0.72 | OPRM1 (0.39) | MAPK1RAB9APOLBMAPTALDH1A1 | |
| SCHEMBL10185867 | 0.71 | CCKBR (0.36) | RAB9AALDH1A1GAAPKM | |
| SCHEMBL10183767 | 0.71 | OPRM1 (0.39) | MAPK1RAB9APOLBMAPT | |
| SCHEMBL10183649 | 0.71 | OPRM1 (0.38) | POLBALDH1A1MEN1KMT2AHTT | |
| SCHEMBL10183904 | 0.71 | OPRM1 (0.38) | MAPK1RAB9APOLBMAPTALDH1A1 | |
| SCHEMBL10183314 | 0.69 | CCKBR (0.37) | MAPK1RAB9APOLBMAPTPKM | |
| SCHEMBL18074198 | 0.68 | SIGMAR1 (0.39) | MAPK1RAB9APOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012009678-A1 | THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHOD OF USE | AGIOS PHARMACEUTICALS, INC. (US) | 2012-01-19 | — | — | WO | disclosed |