Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10184154 | 0.84 | POLB (0.39) | CHRM2CHRM1CHRM3OPRM1OPRK1 | |
| SCHEMBL10183902 | 0.79 | OPRM1 (0.39) | OPRM1OPRK1OPRL1ALDH1A1NPC1 | |
| SCHEMBL10185945 | 0.74 | OPRM1 (0.39) | CHRM2CHRM1CHRM3OPRM1OPRK1 | |
| SCHEMBL10183666 | 0.72 | OPRM1 (0.39) | OPRM1OPRK1OPRL1ALDH1A1POLB | |
| SCHEMBL10184153 | 0.72 | OPRM1 (0.39) | CHRM2CHRM1CHRM3OPRM1OPRK1 | |
| SCHEMBL10185926 | 0.72 | OPRM1 (0.39) | OPRM1OPRK1OPRL1ALDH1A1POLB | |
| SCHEMBL10185869 | 0.71 | OPRM1 (0.40) | OPRM1OPRK1OPRL1ALDH1A1MEN1 | |
| SCHEMBL10184045 | 0.71 | OPRM1 (0.42) | CHRM2CHRM1CHRM3OPRM1OPRK1 | |
| SCHEMBL10183727 | 0.71 | ALDH1A1 (0.41) | OPRM1OPRK1OPRL1ALDH1A1MEN1 | |
| SCHEMBL10185867 | 0.70 | CCKBR (0.36) | OPRM1OPRK1OPRL1ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012009678-A1 | THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHOD OF USE | AGIOS PHARMACEUTICALS, INC. (US) | 2012-01-19 | — | — | WO | disclosed |