Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | DGAT1 | O75907 | 7/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | ACSL3 | O95573 | 1/20 | 0.40 |
| ▸ | ACSL1 | P33121 | 1/20 | 0.40 |
| ▸ | ACSL6 | Q9UKU0 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10185167 | 0.94 | DGAT1 (0.43) | DGAT1PTGDR2NPC1FAAHEPHX2 | |
| SCHEMBL10186435 | 0.91 | HRH3 (0.45) | KDM4EDGAT1SMN1; SMN2ALDH1A1PTGDR2 | |
| SCHEMBL10186424 | 0.90 | ALDH1A1 (0.46) | KDM4EDGAT1SMN1; SMN2ALDH1A1PTGDR2 | |
| SCHEMBL10185026 | 0.89 | HRH3 (0.44) | KDM4EDGAT1SMN1; SMN2ALDH1A1PTGDR2 | |
| SCHEMBL663534 | 0.88 | DGAT1 (0.49) | KDM4EDGAT1SMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL663535 | 0.88 | DGAT1 (0.49) | KDM4EDGAT1SMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL10186133 | 0.88 | DGAT1 (0.49) | KDM4EDGAT1SMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL10185372 | 0.88 | PTGDR2 (0.44) | KDM4EDGAT1SMN1; SMN2ALDH1A1PTGDR2 | |
| SCHEMBL664029 | 0.87 | MAPT (0.47) | KDM4ELMNADGAT1SMN1; SMN2ALDH1A1 | |
| SCHEMBL664030 | 0.87 | MAPT (0.47) | KDM4ELMNADGAT1SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120046292-A1 | DIACYLETHYLENEDIAMINE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2012-02-23 | — | — | US | disclosed |
| WO-2010122968-A1 | DIACYLETHYLENEDIAMINE COMPOUND | アステラス製薬株式会社 (JP) | 2010-10-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120046292-A1 | DIACYLETHYLENEDIAMINE COMPOUND | DGAT1, DGAT2, DIMT1 | KDM4E 3060/4885LMNA 2889/4885HTT 922/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.