Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | CCR3 | P51677 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.41 |
| ▸ | PDE4A | P27815 | 2/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL664029 | 1.00 | MAPT (0.47) | MAPTLMNAHPGDKMT2ATP53 | |
| SCHEMBL10185062 | 0.94 | HPGD (0.47) | MAPTLMNAHPGDKMT2ATP53 | |
| SCHEMBL10186424 | 0.89 | ALDH1A1 (0.46) | SMN1; SMN2KDM4EALDH1A1PTGDR2DGAT1 | |
| SCHEMBL10185133 | 0.89 | LMNA (0.50) | LMNAHPGDKMT2AGAAHSD17B10 | |
| SCHEMBL10186435 | 0.88 | HRH3 (0.45) | KMT2ACCR3SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL10184396 | 0.87 | KDM4E (0.44) | MAPTLMNAHPGDGAASMN1; SMN2 | |
| SCHEMBL10185026 | 0.86 | HRH3 (0.44) | KMT2ASMN1; SMN2KDM4EALDH1A1PTGDR2 | |
| SCHEMBL10184961 | 0.86 | DGAT1 (0.43) | KMT2ACCR3SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL663534 | 0.85 | DGAT1 (0.49) | KMT2ASMN1; SMN2KDM4EALDH1A1DGAT1 | |
| SCHEMBL663535 | 0.85 | DGAT1 (0.49) | KMT2ASMN1; SMN2KDM4EALDH1A1DGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2423182-A1 | DIACYLETHYLENEDIAMINE COMPOUND | Astellas Pharma Inc. (JP) | 2012-02-29 | — | — | EP | disclosed |
| US-20120046292-A1 | DIACYLETHYLENEDIAMINE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2012-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120046292-A1 | DIACYLETHYLENEDIAMINE COMPOUND | DGAT1, DGAT2, DIMT1 | MAPT 2628/4885LMNA 2889/4885HPGD 3492/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.