Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | PPARD | Q03181 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | RORC | P51449 | 1/20 | 0.45 |
| ▸ | DGAT1 | O75907 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | CCR2 | P41597 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | CETP | P11597 | 1/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14984450 | 0.91 | DGAT1 (0.47) | ALDH1A1LMNAMAPTRORCDGAT1 | |
| SCHEMBL13117523 | 0.87 | DGAT1 (0.52) | ALDH1A1LMNAMAPTPPARDSMN1; SMN2 | |
| SCHEMBL10184298 | 0.85 | ALDH1A1 (0.50) | ALDH1A1LMNAMAPTSMN1; SMN2DGAT1 | |
| SCHEMBL10186102 | 0.83 | RAB9A (0.54) | ALDH1A1LMNAMAPTSMN1; SMN2DGAT1 | |
| SCHEMBL10184275 | 0.82 | HPGD (0.54) | ALDH1A1LMNAMAPTSMN1; SMN2POLB | |
| SCHEMBL10186109 | 0.81 | HDAC3 (0.47) | ALDH1A1SMN1; SMN2DGAT1 | |
| SCHEMBL10184835 | 0.81 | HPGD (0.44) | ALDH1A1LMNAMAPTSMN1; SMN2KDM4E | |
| SCHEMBL14984455 | 0.80 | ALDH1A1 (0.52) | ALDH1A1LMNAMAPTDGAT1CYP2C9 | |
| SCHEMBL10188552 | 0.78 | DGAT1 (0.46) | ALDH1A1LMNAMAPTDGAT1KDM4E | |
| SCHEMBL15043518 | 0.78 | ALDH1A1 (0.48) | ALDH1A1LMNAMAPTDGAT1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120046292-A1 | DIACYLETHYLENEDIAMINE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2012-02-23 | — | — | US | disclosed |
| WO-2010122968-A1 | DIACYLETHYLENEDIAMINE COMPOUND | アステラス製薬株式会社 (JP) | 2010-10-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120046292-A1 | DIACYLETHYLENEDIAMINE COMPOUND | DGAT1, DGAT2, DIMT1 | ALDH1A1 963/4885LMNA 2889/4885MAPT 2628/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.