Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 4/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.44 |
| ▸ | ACSL1 | P33121 | 3/20 | 0.42 |
| ▸ | DGAT1 | O75907 | 4/20 | 0.42 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | STAT3 | P40763 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10186202 | 0.92 | DGAT1 (0.45) | HRH3DGAT1SOAT1MAPK14PTGDR2 | |
| SCHEMBL10186204 | 0.92 | CA12 (0.47) | HRH3ACSL1DGAT1SOAT1CHRM4 | |
| SCHEMBL10186471 | 0.91 | DGAT1 (0.48) | HRH3DGAT1SOAT1 | |
| SCHEMBL10184390 | 0.89 | NPC1 (0.48) | HRH3DGAT1SOAT1NPC1HTT | |
| SCHEMBL10185015 | 0.88 | HRH3 (0.42) | HRH3ACSL1DGAT1SOAT1MEN1 | |
| SCHEMBL10185270 | 0.88 | MMP13 (0.57) | MMP13HRH3ACSL1DGAT1MAPK14 | |
| SCHEMBL10185474 | 0.88 | HRH3 (0.45) | HRH3ACSL1DGAT1SOAT1 | |
| SCHEMBL10185026 | 0.87 | HRH3 (0.44) | HRH3DGAT1SOAT1MEN1KMT2A | |
| SCHEMBL10185145 | 0.87 | DGAT1 (0.46) | HRH3DGAT1SOAT1NPC1SMN1; SMN2 | |
| SCHEMBL10186184 | 0.87 | ALDH1A1 (0.44) | HRH3DGAT1SOAT1PTGDR2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120046292-A1 | DIACYLETHYLENEDIAMINE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2012-02-23 | — | — | US | disclosed |
| WO-2010122968-A1 | DIACYLETHYLENEDIAMINE COMPOUND | アステラス製薬株式会社 (JP) | 2010-10-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120046292-A1 | DIACYLETHYLENEDIAMINE COMPOUND | DGAT1, DGAT2, DIMT1 | MMP13 1847/4885HRH3 2422/4885ACSL1 508/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.