Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.56 |
| ▸ | DRD4 | P21917 | 2/20 | 0.56 |
| ▸ | DRD3 | P35462 | 2/20 | 0.56 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.56 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.56 |
| ▸ | PPARG | P37231 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.48 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.47 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7474215 | 0.87 | FFAR1 (0.61) | DRD2DRD4DRD3FFAR1KCNA3 | |
| SCHEMBL839323 | 0.86 | DRD2 (0.71) | DRD2DRD4DRD3FFAR1KCNA3 | |
| SCHEMBL9206786 | 0.84 | KCNA3 (0.73) | DRD2DRD4DRD3KCNA3MEN1 | |
| SCHEMBL20361216 | 0.82 | NPC1 (0.67) | FFAR1GAAMEN1KMT2ANPC1 | |
| SCHEMBL8417765 | 0.81 | KCNA3 (0.61) | KCNA3MEN1KMT2ANPC1RAB9A | |
| SCHEMBL28807540 | 0.81 | FFAR1 (0.60) | DRD2DRD4DRD3FFAR1KCNA3 | |
| SCHEMBL30394052 | 0.80 | MAOB (0.67) | DRD2DRD4DRD3KMT2ARAB9A | |
| SCHEMBL19897758 | 0.80 | MAOB (0.67) | DRD2DRD4DRD3KMT2ARAB9A | |
| SCHEMBL7440812 | 0.80 | KCNH2 (0.56) | DRD2DRD4FFAR1PPARGMEN1 | |
| SCHEMBL4981505 | 0.79 | KCNA3 (0.73) | DRD2DRD4DRD3FFAR1KCNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2780014-A1 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | Constellation Pharmaceuticals, Inc. (US) | 2014-09-24 | — | — | EP | disclosed |
| WO-2013075083-A1 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS (US) | 2013-05-23 | — | — | WO | disclosed |
| US-20120046293-A1 | RENIN INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2012-02-23 | — | — | US | disclosed |
| US-8063105-B2 | Renin inhibitors | MERCK CANADA INC. (CA) | 2011-11-22 | — | — | US | disclosed |
| US-20090281103-A1 | Renin Inhibitors | MERCK CANADA INC. (CA) | 2009-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120046293-A1 | RENIN INHIBITORS | REN, ACE, AGTR1 | DRD2 3736/4885DRD4 3811/4885DRD3 3027/4885 |
| US-20090281103-A1 | Renin Inhibitors | REN, ACE, AGT | DRD2 4051/4885DRD4 3961/4885DRD3 3522/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.