Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.36 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10186643 | 0.91 | SKP2 (0.44) | MEN1KMT2ARAB9ACYP1A2CYP2D6 | |
| SCHEMBL661848 | 0.84 | MEN1 (0.38) | MEN1KMT2ARAB9ACYP1A2CYP2D6 | |
| SCHEMBL14533975 | 0.83 | PARP1 (0.44) | MEN1KMT2ARAB9AHRH3PABPC1 | |
| SCHEMBL10186620 | 0.83 | POLB (0.41) | MEN1KMT2ARAB9ACYP1A2CYP2D6 | |
| Ammonia Solution, Strong SCHEMBL1072026 | 0.82 | MEN1 (0.38) | MEN1KMT2ARAB9ACYP1A2CYP2D6 | |
| SCHEMBL663208 | 0.81 | KDM4E (0.37) | MEN1KMT2ARAB9ACYP1A2CYP2D6 | |
| SCHEMBL12138172 | 0.81 | MAPK14 (0.36) | MEN1KMT2ARAB9ACYP1A2CYP2D6 | |
| SCHEMBL19393101 | 0.81 | HRH3 (0.36) | MEN1KMT2ARAB9AHRH3PABPC1 | |
| Ammonia Solution, Strong SCHEMBL5134889 | 0.80 | MEN1 (0.36) | MEN1KMT2ARAB9ACYP1A2CYP2D6 | |
| SCHEMBL23545671 | 0.78 | TAAR1 (0.44) | MEN1KMT2ARAB9ACYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120046293-A1 | RENIN INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2012-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120046293-A1 | RENIN INHIBITORS | REN, ACE, AGTR1 | MEN1 3395/4885KMT2A 4587/4885RAB9A 205/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.