Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 2/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | IL6 | P05231 | 4/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
| ▸ | AXL | P30530 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.35 |
| ▸ | MERTK | Q12866 | 1/20 | 0.35 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.35 |
| ▸ | CDK7 | P50613 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
| ▸ | CCNH | P51946 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL663467 | 0.95 | ALDH1A1 (0.44) | ALDH1A1TSHRKDM4EPOLBL3MBTL1 | |
| SCHEMBL661943 | 0.86 | ALDH1A1 (0.40) | ALDH1A1TSHRKDM4EPOLBCNR1 | |
| SCHEMBL664743 | 0.86 | ALDH1A1 (0.43) | ALDH1A1TSHRKDM4EPOLBL3MBTL1 | |
| SCHEMBL10186691 | 0.84 | ALDH1A1 (0.43) | ALDH1A1TSHRKDM4EPOLBCNR1 | |
| SCHEMBL1518539 | 0.80 | ALDH1A1 (0.49) | ALDH1A1TSHRKDM4EPOLBCNR1 | |
| SCHEMBL8251206 | 0.80 | ALDH1A1 (0.35) | ALDH1A1TSHRKDM4EPOLBL3MBTL1 | |
| SCHEMBL664766 | 0.79 | ALDH1A1 (0.34) | ALDH1A1TSHRKDM4EPOLBCNR2 | |
| SCHEMBL10186703 | 0.78 | CNR1 (0.34) | ALDH1A1TSHRKDM4EPOLBCNR1 | |
| SCHEMBL88993 | 0.78 | ALDH1A1 (0.40) | ALDH1A1TSHRKDM4EPOLBL3MBTL1 | |
| SCHEMBL10186694 | 0.76 | CNR1 (0.34) | ALDH1A1TSHRKDM4EPOLBCNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120046293-A1 | RENIN INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2012-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120046293-A1 | RENIN INHIBITORS | REN, ACE, AGTR1 | ALDH1A1 2104/4885TSHR 2526/4885KDM4E 3884/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.