Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | ACHE | P22303 | 1/20 | 0.52 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.49 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.49 |
| ▸ | AR | P10275 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | GFER | P55789 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MITF | O75030 | 1/20 | 0.45 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.45 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.45 |
| ▸ | LYN | P07948 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10013917 | 0.89 | ALDH1A1 (0.80) | ALDH1A1L3MBTL1HTTTDP1ACHE | |
| SCHEMBL14159539 | 0.89 | ALDH1A1 (0.80) | ALDH1A1L3MBTL1HTTTDP1ACHE | |
| SCHEMBL30195024 | 0.85 | ALDH1A1 (0.74) | ALDH1A1L3MBTL1HTTTDP1ACHE | |
| SCHEMBL822034 | 0.85 | ALDH1A1 (0.74) | ALDH1A1L3MBTL1HTTTDP1ACHE | |
| SCHEMBL822088 | 0.85 | ALDH1A1 (0.74) | ALDH1A1L3MBTL1HTTTDP1ACHE | |
| SCHEMBL27090239 | 0.85 | SMN1; SMN2 (0.60) | ALDH1A1TDP1GAAGFERSMN1; SMN2 | |
| SCHEMBL29746015 | 0.85 | ALDH1A1 (0.72) | ALDH1A1L3MBTL1HTTTDP1ACHE | |
| SCHEMBL29398372 | 0.85 | ALDH1A1 (0.72) | ALDH1A1L3MBTL1HTTTDP1ACHE | |
| SCHEMBL456868 | 0.85 | ALDH1A1 (0.72) | ALDH1A1L3MBTL1HTTTDP1ACHE | |
| SCHEMBL675770 | 0.83 | ALDH1A1 (0.71) | ALDH1A1L3MBTL1HTTTDP1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8093287-B2 | Inhibitors of matrix metalloproteinases | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2012-01-10 | — | — | US | disclosed |
| US-20110224275-A1 | INHIBITORS OF MATRIX METALLOPROTEINASES | NOTRE DAME UNIVERSITY (US) | 2011-09-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110224275-A1 | INHIBITORS OF MATRIX METALLOPROTEINASES | MMP9, MMP1, MMP2 | ALDH1A1 403/4885L3MBTL1 4619/4885HTT 2549/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.