SCHEMBL10187648

SCHEMBL10187648

CCc1cc(Oc2ccc(F)cc2)ccc1C1=C(O)CCC1=O

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.36
MAPT P10636 1/20 0.36
PKM P14618 1/20 0.36
HTT P42858 1/20 0.36
KMT2A Q03164 1/20 0.36
SCN9A Q15858 3/20 0.36
LTB4R Q15722 1/20 0.35
HSD17B1 P14061 1/20 0.35
MAOB P27338 3/20 0.35
MAOA P21397 1/20 0.35
PPARG P37231 3/20 0.35
PPARD Q03181 1/20 0.35
PPARA Q07869 1/20 0.35
S1PR2 O95136 3/20 0.35
HTR2A P28223 1/20 0.34
SLC6A4 P31645 1/20 0.34
KCNH2 Q12809 1/20 0.34
GRM5 P41594 1/20 0.34
HSPB1 P04792 1/20 0.33
LIPG Q9Y5X9 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10196154 0.90 LTB4R (0.37) MEN1MAPTPKMHTTKMT2A
SCHEMBL516287 0.88 MAOB (0.36) MEN1KMT2AHSD17B1MAOBMAOA
SCHEMBL10195110 0.83 MAOA (0.39) MEN1MAPTPKMHTTKMT2A
SCHEMBL10196167 0.78 MAOB (0.42) MEN1MAPTHTTKMT2AHSD17B1
SCHEMBL10196155 0.78 MAOA (0.39) MEN1KMT2AHSD17B1MAOBMAOA
SCHEMBL10196168 0.76 HTR2A (0.40) MAPTKMT2APPARGPPARAHTR2A
SCHEMBL10195109 0.76 SMN1; SMN2 (0.39) MEN1MAPTPKMHTTKMT2A
SCHEMBL10195145 0.75 S1PR2 (0.36) MEN1MAPTPKMHTTKMT2A
SCHEMBL12119160 0.75 HSD17B1 (0.43) MAPTHTTHSD17B1
SCHEMBL10192905 0.75 PPARG (0.35) MEN1MAPTPKMHTTKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8680339-B2 Herbicides SYNGENTA LIMITED (GB) 2014-03-25 US disclosed
US-8680339-B2 Herbicides SYNGENTA LIMITED (GB) 2014-03-25 US disclosed
US-20120028800-A1 NOVEL HERBICIDES SYNGENTA CROP PROTECTION LLC (US) 2012-02-02 US disclosed
US-20120028800-A1 NOVEL HERBICIDES SYNGENTA CROP PROTECTION LLC (US) 2012-02-02 US disclosed
WO-2010089210-A1 NOVEL HERBICIDES SYNGENTA LIMITED (GB) 2010-08-12 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120028800-A1 NOVEL HERBICIDES DDT, CYP4X1, CYP1B1 MEN1 4280/4885MAPT 3903/4885PKM 2307/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.