Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 7/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1126692 | 0.83 | SIRT6 (0.57) | SIRT6MAPTALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL942671 | 0.80 | MAPT (0.51) | MAPTALDH1A1LMNASMN1; SMN2POLB | |
| SCHEMBL22495369 | 0.77 | SIRT6 (0.50) | SIRT6MAPTALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL6151230 | 0.75 | SIRT6 (0.81) | SIRT6MAPTALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL15271381 | 0.75 | SIRT6 (0.81) | SIRT6MAPTALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL14618026 | 0.74 | HTR3A (0.62) | ALDH1A1 | |
| SCHEMBL1127229 | 0.74 | KMT2A (0.66) | SIRT6MAPTALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL13362485 | 0.74 | PDE10A (0.55) | — | |
| SCHEMBL14818715 | 0.74 | PDE10A (0.59) | — | |
| SCHEMBL1018619 | 0.73 | POLB (0.55) | SIRT6MAPTALDH1A1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2097413-B1 | 2-[(2-SUBSTITUTED)-IND0LIZIN-3-YL]-2-OXO-ACETAMIDE DERIVATIVES AS ANTIFUNGAL AGENTS | F2G LTD (GB) | 2013-12-25 | — | — | EP | disclosed |
| EP-2173749-B1 | 2-OXO-2- (2-PHENYL-5,6,7,8-TETRAHYDRO-INDOLIZIN-3-YL) -ACETAMIDE DERIVATIVES AND RELATED COMPOUNDS AS ANTIFUNGAL AGENTS | F2G LTD (GB) | 2011-01-12 | — | — | EP | disclosed |