Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 16/20 | 0.52 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | SOAT2 | O75908 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | SCD | O00767 | 1/20 | 0.40 |
| ▸ | FADS1 | O60427 | 1/20 | 0.40 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL901694 | 0.93 | DGAT1 (0.52) | DGAT1SOAT1KCNH2ADORA2ASCD | |
| SCHEMBL10189113 | 0.90 | DGAT1 (0.64) | DGAT1SOAT1SCD | |
| SCHEMBL10189571 | 0.88 | DGAT1 (0.40) | DGAT1SOAT1KCNH2SCDFADS1 | |
| SCHEMBL10381835 | 0.83 | DGAT1 (0.59) | DGAT1KCNH2ADORA2ACYP3A4CYP2C9 | |
| SCHEMBL10189564 | 0.82 | DGAT1 (0.47) | DGAT1SOAT1KCNH2 | |
| SCHEMBL10189649 | 0.80 | DGAT1 (0.52) | DGAT1SOAT1SCD | |
| SCHEMBL10189555 | 0.79 | SCD (0.54) | CYP1A2CYP3A4CYP2C9CYP2C19SCD | |
| SCHEMBL10189215 | 0.78 | DGAT1 (0.49) | DGAT1SOAT1SCD | |
| SCHEMBL902790 | 0.77 | DGAT1 (0.51) | DGAT1SOAT1KCNH2ADORA2ASOAT2 | |
| SCHEMBL902462 | 0.77 | DGAT1 (0.73) | DGAT1SOAT1KCNH2ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012044567-A2 | IMIDAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2012-04-05 | — | — | WO | disclosed |