Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 10/20 | 0.52 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.46 |
| ▸ | FASN | P49327 | 9/20 | 0.44 |
| ▸ | RHEB | Q15382 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL901002 | 0.81 | DGAT1 (0.74) | DGAT1SOAT1KCNH2ADORA2AFASN | |
| SCHEMBL10189188 | 0.81 | DGAT1 (0.56) | DGAT1SOAT1KCNH2ADORA2ARHEB | |
| SCHEMBL10188914 | 0.80 | DGAT1 (0.69) | DGAT1SOAT1KCNH2ADORA2A | |
| SCHEMBL902450 | 0.80 | DGAT1 (0.60) | DGAT1SOAT1RHEB | |
| SCHEMBL901150 | 0.79 | DGAT1 (0.53) | DGAT1SOAT1KCNH2ADORA2AFASN | |
| SCHEMBL901744 | 0.77 | DGAT1 (0.58) | DGAT1SOAT1KCNH2ADORA2A | |
| SCHEMBL10188661 | 0.77 | DGAT1 (0.46) | DGAT1SOAT1KCNH2ADORA2A | |
| SCHEMBL901616 | 0.77 | DGAT1 (0.46) | DGAT1SOAT1 | |
| SCHEMBL901818 | 0.76 | DGAT1 (0.49) | DGAT1SOAT1KCNH2 | |
| SCHEMBL15073266 | 0.75 | DGAT1 (0.52) | DGAT1KCNH2ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012044567-A2 | IMIDAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2012-04-05 | — | — | WO | disclosed |