Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 14/20 | 0.49 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.49 |
| ▸ | TNKS | O95271 | 5/20 | 0.41 |
| ▸ | TNKS2 | Q9H2K2 | 5/20 | 0.41 |
| ▸ | PARP1 | P09874 | 3/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10189188 | 0.82 | DGAT1 (0.56) | DGAT1SOAT1KCNH2 | |
| SCHEMBL901631 | 0.79 | CDK9 (0.32) | DGAT1 | |
| SCHEMBL902450 | 0.77 | DGAT1 (0.60) | DGAT1SOAT1 | |
| SCHEMBL10188661 | 0.76 | DGAT1 (0.46) | DGAT1SOAT1KCNH2 | |
| SCHEMBL10189104 | 0.76 | DGAT1 (0.52) | DGAT1SOAT1KCNH2 | |
| SCHEMBL16661140 | 0.73 | DGAT1 (0.47) | DGAT1SOAT1 | |
| SCHEMBL902462 | 0.72 | DGAT1 (0.73) | DGAT1SOAT1KCNH2 | |
| SCHEMBL902547 | 0.71 | DGAT1 (0.78) | DGAT1SOAT1KCNH2 | |
| SCHEMBL10189200 | 0.70 | DGAT1 (0.71) | DGAT1SOAT1KCNH2 | |
| SCHEMBL902024 | 0.70 | DGAT1 (0.43) | DGAT1SOAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012044567-A2 | IMIDAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2012-04-05 | — | — | WO | disclosed |