Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 8/20 | 0.60 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.60 |
| ▸ | MMP2 | P08253 | 1/20 | 0.53 |
| ▸ | MMP9 | P14780 | 1/20 | 0.53 |
| ▸ | MMP8 | P22894 | 1/20 | 0.53 |
| ▸ | MMP13 | P45452 | 1/20 | 0.53 |
| ▸ | RHEB | Q15382 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.49 |
| ▸ | RELA | Q04206 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.48 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10189188 | 0.82 | DGAT1 (0.56) | DGAT1SOAT1RHEBCHEK2 | |
| SCHEMBL20982471 | 0.80 | MMP2 (0.78) | MMP2MMP9MMP8MMP13RHEB | |
| SCHEMBL10189104 | 0.80 | DGAT1 (0.52) | DGAT1SOAT1RHEB | |
| SCHEMBL10189200 | 0.79 | DGAT1 (0.71) | DGAT1SOAT1 | |
| SCHEMBL14984444 | 0.78 | ALDH1A1 (0.48) | DGAT1KDM4ENPC1ALDH1A1LMNA | |
| SCHEMBL901818 | 0.77 | DGAT1 (0.49) | DGAT1SOAT1 | |
| SCHEMBL19763371 | 0.76 | CHEK2 (0.72) | MMP2MMP9MMP8MMP13RHEB | |
| SCHEMBL902547 | 0.75 | DGAT1 (0.78) | DGAT1SOAT1 | |
| SCHEMBL19747752 | 0.75 | MMP2 (0.70) | MMP2MMP9MMP8MMP13RHEB | |
| SCHEMBL2617479 | 0.74 | KDM4E (0.71) | MMP2MMP9MMP8MMP13RHEB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012044567-A2 | IMIDAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2012-04-05 | — | — | WO | disclosed |