Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10284425 | 0.81 | GAA (0.41) | GAAHPGDRAPGEF4ALDH1A1CYP1A2 | |
| SCHEMBL14001504 | 0.78 | IDO1 (0.37) | GAAALDH1A1KDM4EHTTMAPT | |
| Hydrochloric Acid SCHEMBL28168851 | 0.76 | IDO1 (0.36) | GAAALDH1A1KDM4EHTTMAPT | |
| SCHEMBL11855115 | 0.75 | NPC1 (0.42) | GAAHPGDALDH1A1KDM4ECYP1A2 | |
| SCHEMBL183133 | 0.74 | CYP3A4 (0.52) | GAAALDH1A1KDM4ECYP1A2MAPT | |
| SCHEMBL838148 | 0.73 | RAPGEF4 (0.54) | GAARAPGEF4ALDH1A1KDM4ECYP1A2 | |
| SCHEMBL30951588 | 0.73 | RAPGEF4 (0.54) | GAARAPGEF4ALDH1A1KDM4ECYP1A2 | |
| SCHEMBL12589735 | 0.73 | RAB9A (0.50) | GAAHPGDRAPGEF4ALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL31082291 | 0.71 | RAPGEF4 (0.52) | GAARAPGEF4ALDH1A1KDM4ECYP1A2 | |
| Hydrochloric Acid SCHEMBL839579 | 0.71 | RAPGEF4 (0.52) | GAARAPGEF4ALDH1A1KDM4ECYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8193168-B2 | Use of a TRPM5 inhibitor to regulate insulin and GLP-1 release | REDPOINT BIO CORPORATION (US) | 2012-06-05 | — | — | US | disclosed |