Sugi Predict

Sugi Predict / Compounds / SCHEMBL1018965

SCHEMBL1018965

SCHEMBL1018965

CC1(C)Cc2cccc(C(=O)Cl)c2O1

nearest known ligand 0.61

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ PKM P14618 2/20 0.61
▸ NPSR1 Q6W5P4 1/20 0.61
▸ LMNA P02545 3/20 0.58
▸ ALDH1A1 P00352 3/20 0.54
▸ KDM4E B2RXH2 1/20 0.54
▸ MAPT P10636 3/20 0.53
▸ NPC1 O15118 3/20 0.46
▸ RAB9A P51151 2/20 0.46
▸ POLB P06746 2/20 0.43
▸ KMT2A Q03164 2/20 0.43
▸ MEN1 O00255 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19151057 0.85 LMNA (0.63) PKMNPSR1LMNAALDH1A1KDM4E
SCHEMBL783714 0.85 LMNA (0.59) PKMNPSR1LMNAALDH1A1KDM4E
SCHEMBL15947265 0.84 LMNA (0.58) PKMNPSR1LMNAALDH1A1KDM4E
SCHEMBL19151164 0.81 LMNA (0.55) PKMNPSR1LMNAALDH1A1KDM4E
SCHEMBL6612160 0.81 LMNA (0.59) PKMNPSR1LMNAALDH1A1KDM4E
SCHEMBL20646883 0.81 LMNA (0.55) PKMNPSR1LMNAALDH1A1KDM4E
SCHEMBL2434076 0.78 LMNA (0.52) PKMNPSR1LMNAALDH1A1KDM4E
SCHEMBL5837384 0.77 LMNA (0.71) LMNAALDH1A1MAPTNPC1RAB9A
SCHEMBL7626504 0.76 HTR2A (0.50) PKMNPSR1LMNAALDH1A1MAPT
SCHEMBL10737745 0.74 PKM (0.50) PKMNPSR1LMNAALDH1A1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 60 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12247027-B2 P2X7 modulators JANSSEN PHARMACEUTICA NV (BE) 2025-03-11 — — US disclosed
US-20240116930-A1 P2X7 MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2024-04-11 — — US disclosed
US-11820770-B2 P2X7 modulators JANSSEN PHARMACEUTICA NV (BE) 2023-11-21 — — US disclosed
US-20220213095-A1 P2X7 MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2022-07-07 — — US disclosed
US-11225478-B2 P2X7 modulators JANSSEN PHARMACEUTICA NV (BE) 2022-01-18 — — US disclosed
CN-110003200-B P2X7 modulators 詹森药业有限公司 2021-11-26 — — CN disclosed
US-20200325138-A1 P2X7 Modulators JANSSEN PHARMACEUTICA NV (BE) 2020-10-15 — — US disclosed
US-10703749-B2 P2X7 modulators JANSSEN PHARMACEUTICA NV (BE) 2020-07-07 — — US disclosed
EP-3495365-A1 P2X7 MODULATORS Janssen Pharmaceutica NV (BE) 2019-06-12 — — EP disclosed
US-20190092770-A1 P2X7 Modulators JANSSEN PHARMACEUTICA NV (BE) 2019-03-28 — — US disclosed
WO-2008151211-A1 SUBSTITUTED BENZOYLAMINO-INDAN-2-CARBOXYLIC ACIDS AND RELATED COMPOUNDS SANOFI-AVENTIS (FR) 2008-12-11 — — WO disclosed
US-20080292585-A1 Azonafide Derivatives, Methods for Their Production and Pharmaceutical Compositions Therefrom UNIBIOSCREEN S.A. (BE) 2008-11-27 — — US disclosed
EP-1981504-A2 THIADIAZOLE DERIVATIVES FOR THE TREATMENT OF NEURO DEGENERATIVE DISEASES NV Remynd (BE) 2008-10-22 — — EP disclosed
EP-1963255-A1 SYNEPHRINE DERIVATIVES USEFUL AS ANTI-INFLAMMATORY AGENTS UNIVERSITEIT GENT (BE) 2008-09-03 — — EP disclosed
EP-1960365-A2 AZONAFIDE DERIVATIVES, METHODS FOR THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS THEREFROM Unibioscreen S.A. (BE) 2008-08-27 — — EP disclosed
WO-2008061781-A1 THIADIAZOLE DERIVATIVES FOR THE TREATMENT OF NEURO-DEGENERATIVE DISEASES NV REMYND (BE) 2008-05-29 — — WO disclosed
US-20080058335-A1 NOVEL COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS AND USES THEREOF ABBVIE INC. 2008-03-06 — — US disclosed
WO-2007090617-A2 THIADIAZOLE DERIVATIVES FOR THE TREATMENT OF NEURO DEGENERATIVE DISEASES NV REMYND (BE) 2007-08-16 — — WO disclosed
WO-2007071452-A1 SYNEPHRINE DERIVATIVES USEFUL AS ANTI-INFLAMMATORY AGENTS UNIVERSITEIT GENT (BE) 2007-06-28 — — WO disclosed
WO-2007054292-A2 AZONAFIDE DERIVATIVES, METHODS FOR THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS THEREFROM UNIBIOSCREEN S.A. (BE) 2007-05-18 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200325138-A1 P2X7 Modulators P2RX2, P2RX7, P2RY2 PKM 1079/4885NPSR1 141/4885LMNA 2272/4885
US-12247027-B2 P2X7 modulators P2RX2, P2RX7, P2RY2 PKM 1079/4885NPSR1 141/4885LMNA 2272/4885
US-20190092770-A1 P2X7 Modulators P2RX2, P2RX7, P2RY2 PKM 1079/4885NPSR1 141/4885LMNA 2272/4885
US-11225478-B2 P2X7 modulators P2RX2, P2RX7, P2RY2 PKM 1079/4885NPSR1 141/4885LMNA 2272/4885
US-20080292585-A1 Azonafide Derivatives, Methods for Their Production and Pharmaceutical Compositions Therefrom AADAC, NOTUM, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 PKM 1022/4885NPSR1 4113/4885LMNA 3175/4885
US-11820770-B2 P2X7 modulators P2RX2, P2RX7, P2RY2 PKM 1079/4885NPSR1 141/4885LMNA 2272/4885
US-20220213095-A1 P2X7 MODULATORS P2RX2, P2RX7, P2RY2 PKM 1079/4885NPSR1 141/4885LMNA 2272/4885
US-20240116930-A1 P2X7 MODULATORS P2RX2, P2RX7, P2RY2 PKM 1079/4885NPSR1 141/4885LMNA 2272/4885
US-10703749-B2 P2X7 modulators P2RX2, P2RX7, P2RY2 PKM 1079/4885NPSR1 141/4885LMNA 2272/4885
US-20080058335-A1 NOVEL COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS AND USES THEREOF CNR1, CNR2, OPRL1 PKM 2961/4885NPSR1 4/4885LMNA 1150/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.