Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 14/20 | 0.40 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | SCD | O00767 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10189564 | 0.90 | DGAT1 (0.47) | DGAT1SOAT1 | |
| SCHEMBL10189215 | 0.76 | DGAT1 (0.49) | DGAT1SOAT1SCDMEN1NPC1 | |
| SCHEMBL10189113 | 0.75 | DGAT1 (0.64) | DGAT1SOAT1SCD | |
| SCHEMBL10189666 | 0.75 | DGAT1 (0.56) | DGAT1SOAT1ALDH1A1 | |
| SCHEMBL10189649 | 0.73 | DGAT1 (0.52) | DGAT1SOAT1SCD | |
| SCHEMBL10188929 | 0.73 | DGAT1 (0.52) | DGAT1SOAT1SCD | |
| SCHEMBL901694 | 0.71 | DGAT1 (0.52) | DGAT1SOAT1SCD | |
| SCHEMBL10189571 | 0.69 | DGAT1 (0.40) | DGAT1SOAT1SCD | |
| SCHEMBL10188661 | 0.67 | DGAT1 (0.46) | DGAT1SOAT1 | |
| SCHEMBL902394 | 0.65 | DGAT1 (0.65) | DGAT1SOAT1SCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012044567-A2 | IMIDAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2012-04-05 | — | — | WO | disclosed |